Cat. No. | Product Name | Target | Signaling Pathways |
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T72403 |
Ferroptosis inducer-1
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Ferroptosisinducer-1 是一种铁凋亡 (Ferroptosis) 诱导剂,具有抗肿瘤的潜力。 | |||
T74069 |
Fluorescein-diisobutyrate-6-amide
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Fluorescein-diisobutyrate-6-amide,作为一种有效的铁死亡(ferroptosis)诱导剂,展示了其在癌症研究中的潜力。 | |||
T79777 |
GPX4-IN-7
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Ferroptosis | Apoptosis |
GPX4-IN-7 (Compound 31),一种靛玉红衍生物,作为结肠癌铁死亡的诱导剂,对HCT-116细胞显示出卓越的抗肿瘤效果,IC50为0.49 μM。该化合物通过促进GPX4降解和脂质ROS积累,有效触发铁死亡。 | |||
T79639 | Lepadin H | Ferroptosis | Apoptosis |
Lepadin H 是一种具有显著细胞毒性的海洋生物碱,能够诱导铁死亡。它通过增加 p53 表达、提升 ROS 生成和脂质过氧化来展开作用,同时抑制 SLC7A11 和 GPX4,上调 ACSL4。Lepadin H 主要通过 p53-SLC7A11-GPX4 路径实现其诱导铁死亡的功能。 | |||
T37851 |
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging... | |||
T35994 |
Erastin2
Erastin2 |
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Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).[2] It induces cell death in HAP1 cells when used at a concentration of 5 µM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine . [1] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect that can be blocked by the reducing agent β-merc... | |||
T79359 | Anticancer agent 147 | Ferroptosis | Apoptosis |
Anticanceragent 147(化合物6j),作为槐定碱的衍生物,功能为铁死亡(Ferroptosis)诱导剂。该化合物能促进Fe2+、活性氧(ROS)及丙二醛(MDA)在细胞内的积累,并通过增加内质网(ER)应激和上调转录因子ATF3的表达发挥作用。在体外及体内实验中,Anticanceragent 147展现了出色的抗肝癌活性。 | |||
T36882 |
CAY10773
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CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen ... |