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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39057 |
Rozanolixizumab
UCB7665 |
Others | Others |
Rozanolixizumab(RYSTIGGO)是一种针对人类新生儿 Fc 受体(FcRn)的高亲和力人源化免疫球蛋白 G4 单克隆抗体,用于研究自身免疫和同种免疫疾病中致病性 IgG 。 | |||
T9901A-010 |
Tifalibep
ABY-039 |
||
Tifalibep (ABY-039) 是一种二价抗 FcRn 抗体模拟物,可以用于治疗抗体(IgG)介导的自身免疫。 | |||
T78245 |
Batoclimab
IMVT-1401,HBM9161 |
||
Batoclimab是一款针对人FcRn的单克隆抗体,该药物可用于研究由致病性IgG抗体介导的自身免疫性疾病。 | |||
T78249 |
Nipocalimab
M281 |
||
Nipocalimab (M281)为全人源重组非糖基化IgG1型单克隆抗体。该抗体作为去糖基化IgG1对抗FcRn,能够在体内pH 6.0与胞外pH 7.6的条件下,以皮摩尔级别的亲和力与Fc受体(FcRn)结合。 | |||
T78325 |
Orilanolimab
SYNT001 |
||
Orilanolimab (SYNT001) 是一种人源化、去免疫化的单克隆抗体,具有阻断FcRn功能。它可以干预FcRn与IgG分子的 Fc 部分之间的相互作用,并妨碍IgGIC 通过激活FcRn介导的免疫反应,影响与IgG相关的稳态以及先天性和适应性免疫功能。 | |||
T77190 | Crovalimab | ||
Crovalimab (SKY59; RO7112689)是一种人源化抗C5抗体,其通过pH依赖性机制发挥作用,其KD值在pH 7.4时为15.2nM,在pH 5.8时为16.8μM。该化合物还以高亲和力结合于人FcRn(KD: 17μM; pH 6.0)。通过阻断C5转化酶对C5的切割及抑制C5变体(p.Arg885His)的活性,Crovalimab能够显著抑制补体系统中经典途径(CP)、凝集素途径(LP)以及旁路途径(AP)中C5b-9的形成。因此,Crovalimab展现出作为研究阵发性睡眠性血红蛋白尿(PNH)及其他补体介导疾病的潜力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02811 |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His)
Fc fragment of IgG, receptor, transporter, alpha,FcRn |
Mouse | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is Q61559&P01887. | |||
TMPY-05539 |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated
Fc fragment of IgG, receptor, transporter, α,FCRN,α... |
Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is P55899&P61769. | |||
TMPY-02082 |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His)
Fc fragment of IgG, receptor, transporter, alpha,alpha-chain... |
Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is P55899-1&P61769. | |||
TMPY-05147 |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His), Biotinylated
Fc fragment of IgG, receptor, transporter, alpha,FcRn |
Mouse | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is Q61559&P01887. | |||
TMPY-05649 |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His & Avi), Biotinylated
Fc fragment of IgG, receptor, transporter, alpha,Fc fragment... |
Mouse | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 46 kDa and the accession number is Q61559. | |||
TMPY-05036 |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi)
Fc fragment of IgG, receptor, transporter, alpha,α-chain, |
Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.3 kDa and the accession number is NP_004098.1&NP_004039.1. | |||
TMPY-05448 |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi), Biotinylated
Fc fragment of IgG, receptor, transporter, alpha,alpha-chain... |
Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.3 kDa and the accession number is NP_004098.1&NP_004039.1. | |||
TMPH-01517 |
FCGRT Protein, Human, Recombinant (GST)
|
Human | E. coli |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and exten... | |||
TMPH-01516 |
FCGRT Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and exten... | |||
TMPK-01115 |
Fc gamma RIII/CD16 Protein, Cynomolgus, Recombinant (His)
FcgRIII,FCR-10,FcRIII,IMD20,FCG3,CD16A,FCGR3,Fc-gamma RIII,I... |
Cynomolgus | HEK293 Cells |
Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set. |