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Cat. No. Product Name Target Signaling Pathways
T74754 FXR antagonist 2

Compound A-26, also known as FXR antagonist 2, is a diarylamide derivative that functions as a moderate FXR antagonist. It is utilized in researching hyperlipidemia and type 2 diabetes [1].

化合物

FXR antagonist 2
Cat.No: T74754
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T81030 Tauro-β-muricholic acid

TβMCA

FXR Metabolism
Tauro-β-muricholic acid (TβMCA) 为一种具有三羟基结构的胆汁酸,是FXR的竞争性、可逆拮抗剂,IC50值为40 μM。此外,Tauro-β-muricholic acid 能够通过维持线粒体膜电位来阻抑胆汁酸引起的肝细胞凋亡,发挥抗凋亡功能。
T36563 (E)-Guggulsterone

Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Tauro-β-muricholic acid
Cat.No: T81030
Synonym: TβMCA
Target: FXR
(E)-Guggulsterone
Cat.No: T36563
Synonym:
Target:
TargetMol Loading
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