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Search Results for " fth1 "

Targets Recommended: Ferroptosis

1

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T60202	MMRi62 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol	Ferroptosis	Apoptosis
	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) 是一种铁死亡 (ferroptosis) 诱导剂，靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (apoptosis) 活性，并诱导其自噬 (autophagy)。MMRi62 诱导铁死亡，伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解，并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。

化合物

Cat.No: T60202

Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Target: Ferroptosis

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00761	FTH Protein, Human, Recombinant (His) FTHL6,Cell proliferation-inducing gene 15 ...	Human	E. coli
	Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is composed of 24 subunits of the light and heavy ferritin chains. It plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney. Variation of...
TMPY-02711	Ferritin heavy chain 1/FTH1 Protein, Human, Recombinant FHC,FTHL6,FTH,PIG15,PLIF,ferritin...	Human	E. coli
	FTH1 (ferritin, heavy polypeptide 1) is the heavy subunit of ferritin which is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative dis...
TMPY-04137	ATP6V1F Protein, Human, Recombinant (GST) Vma7,ATPase, H+ transporting, lysosomal 14kDa, V	Human	E. coli
	ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using reverse transcription polymerase chain reaction and touchdown-polymerase chain reaction, respectively. Topology prediction showed that there is one protein kinase C phosphorylation site, two Casein kinase II phosphorylation sites, and one N-myristoylation site in the ATP6V1F protein. U...
TMPJ-00886	ATF1 Protein, Human, Recombinant (His) Cyclic AMP-dependent transcription factor ATF-1,Act...	Human	E. coli
	Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the ...

重组蛋白

FTH Protein, Human, Recombinant (His)

Cat.No: TMPJ-00761

Species: Human

Expression System: E. coli

Ferritin heavy chain 1/FTH1 Protein, Human, Recombinant

Cat.No: TMPY-02711

Species: Human

Expression System: E. coli

ATP6V1F Protein, Human, Recombinant (GST)

Cat.No: TMPY-04137

Species: Human

Expression System: E. coli

ATF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00886

Species: Human

Expression System: E. coli

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