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Cat. No.	Product Name	Target	Signaling Pathways
T82392	FLT3-IN-23
	FLT3-IN-23作为JFMS样脂氨酸激酶3(FLT3)的抑制剂，表现出7.42 nM的IC50值。该化合物针对带有多种FLT3-TKD与FLT3-ITD-TKD突变的BaF3细胞显示出显著的抗增殖效果。
T6020	Pacritinib SB1518	FLT; Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Pacritinib (SB1518) 是一种野生型 JAK2和 JAK2V617F 突变型抑制剂，IC50分别为 23 和 19 nM。它也抑制 FLT3及其突变型 FLT3D835Y，IC50分别为 22 和 6 nM。
T64283	Pacritinib hydrochloride
	Pacritinib hydrochloride 是一种野生型 JAK2 (IC50: 23 nM) 和 JAK2V617F 突变型 (IC50: 19 nM) 的有效抑制剂。Pacritinib hydrochloride 也能够抑制 FLT3 (IC50: 22 nM) 及其突变型 FLT3D835Y (IC50: 6 nM)。Pacritinib hydrochloride 能够用于研究急性髓系白血病(AML)和骨髓纤维化(MF)。
T71382	KRC-108
	KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumo...