Cat. No. | Product Name | Target | Signaling Pathways |
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T6834 |
FCCP
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone |
ATPase; Mitochondrial Metabolism | Membrane transporter/Ion channel; Metabolism |
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂,线粒体质子载体解偶联剂。FCCP 常被用作细胞凋亡诱导剂。 | |||
T35962 |
MitoPBN
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MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radical... |