Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15271 |
Denifanstat
FASN-IN-2,TVB2640,TVB-2640 |
Fatty Acid Synthase | Metabolism |
Denifanstat (FASN-IN-2) 是一种口服具有活性的选择性 FASN 抑制剂,IC50=0.052 μM,EC50=0.072 μM。它有用于脂肪肝和癌症的研究潜力。 | |||
T21831 |
UCM05
G28UCM |
Fatty Acid Synthase | Metabolism |
UCM05 (G28UCM) (G28UCM) 是一种有效的脂肪酸合酶 (FASN) 抑制剂,对 HER2+ 乳腺癌异种移植物具有作用活性,且在抗 HER2 耐药细胞系中具有活性。UCM05 是一种丝状温度敏感蛋白 Z (FtsZ) 抑制剂,可抑制革兰氏阳性菌B. subtilis 生长,MIC 值为 100 μM,但对革兰氏阴性菌E. coli 缺乏活性。 | |||
T37776 | FASN-IN-4 tosylate | ||
FASN-IN-4 tosylate 是高效的脂肪酸合酶 FASN 抑制剂,IC50值为 10 nM。FASN-IN-4 tosylate 还抑制 SARS-CoV-2,EC50为 18.6 nM。 | |||
T70882 |
Orlistat-d3
|
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Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit... |