首页 工具
登录
购物车

搜索结果

Search Results for " exportin 1 "

4

抑制剂 & 化合物

1

天然产物

如果没找到您满意的产品或者您对产品有其他要求,可以联系我们专业顾问为您提供针对性的合理建议。     QQ咨询       网站留言咨询

提交您的定制咨询

点击图片重新获取验证码
Cat. No. Product Name Target Signaling Pathways
T24269 KPT-251

KPT251

Others Others
KPT-251 是一种选择性核输出抑制剂。
T15735 Leptomycin B

CI 940,LMB,来普霉素B

CRM1; Antibiotic; Antifungal Membrane transporter/Ion channel; Microbiology/Virology
Leptomycin B (LMB) 是一种抗真菌抗生素,可阻断真核细胞周期,抑制蛋白出核转运。Leptomycin 通过半胱氨酸残基处的共价修饰使 CRM1/exportin 1失活。它
T11766L Eltanexor

ONO-7706,KPT-8602,ATG-016

Others Others
Eltanexor (ONO-7706) 是一种具有口服活性的 exportin-1 (XPO1) 抑制剂。它具有有效的抗白血病活性。 Eltanexor 通过直接靶向 XPO1 抑制 XPO1 依赖性核输出 (EC50=60.9 nM)。 Eltanexor 在一组白血病细胞系中引起半胱天冬酶依赖性细胞凋亡。
T70180 LFS-829

LFS-829 is a a small-molecule antagonist of exportin-1. LFS-829 showed low-range nanomolar activities. Oral administration of LFS-829 can significantly reverse the pathological features of colitis model mice. LFS-829 can attenuate dual NF-κB signaling and the Nrf2 cytoprotection pathway via targeting exportin-1 in colitis mice. Moreover, LFS-829 has a very low risk of cardiotoxicity and acute toxicity. LFS-829 holds great promise for the treatment of colitis and may warrant translation for use i...

化合物

KPT-251
Cat.No: T24269
Synonym: KPT251
Target: Others
Leptomycin B
Cat.No: T15735
Synonym: CI 940,LMB,来普霉素B
Target: CRM1, Antibiotic, Antifungal
Eltanexor
Cat.No: T11766L
Synonym: ONO-7706,KPT-8602,ATG-016
Target: Others
LFS-829
Cat.No: T70180
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T11837 Leptomycin A

CRM1 Membrane transporter/Ion channel
Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the interaction between CRM1 and nuclear export signals, effectively hindering the nuclear export of a wide array of proteins.

天然产物

Leptomycin A
Cat.No: T11837
Synonym:
Target: CRM1
TargetMol Loading
联系我们
400-820-0310

上海市静安区江场三路238号8楼