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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T72934	Epothilone E 埃博霉素E
	Epothilone E，作为Epothilone的衍生化合物，通过抑制微管蛋白功能来阻碍细胞分裂，从而展现出抗肿瘤活性。
T6075	Epothilone B 帕妥匹隆,Patupilone,EPO 906	Apoptosis; Microtubule Associated; Antibiotic; Antifungal	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology
	Epothilone B (EPO 906) 是微管稳定剂，Ki 为0.71 μM。它与αβ-微管蛋白异二聚体亚基结合，使αβ-微管蛋白解离减少。
T31657	Epothilone F
	Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F prevents cancer cells from dividing
T68232	Epofolate
	Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and s...
T71577	KOS-1584
	KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration,...
T69480	Sagopilone
	Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites wa...
T68860	Iso-Fludelone
	Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as we...

化合物

Synonym: 帕妥匹隆,Patupilone,EPO 906

Target: Apoptosis, Microtubule Associated, Antibiotic, Antifungal

Cat. No.	Product Name	Target	Signaling Pathways
T6490	Epothilone A 埃博霉素 A,epothile,Epo A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Epothilone A (Epo A) 是紫杉醇和管蛋白聚合物结合的一种竞争性抑制剂，其Ki 值为 0.6-1.4 μM。
T82453	Epothilone D1
	Epothilone D1为分离得到的天然产物，展现对小鼠成纤维细胞的细胞毒性。

天然产物

Epothilone A

Cat.No: T6490

Synonym: 埃博霉素 A,epothile,Epo A

Target: Apoptosis, Microtubule Associated

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