Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9205 |
NCGC00378430
|
Phosphatase; Others | Metabolism; Others |
NCGC00378430 是一种 SIX1/EYA2 相互作用抑制剂。它部分逆转 SIX1 过表达介导的转录和代谢谱,并逆转 SIX1 诱导的 TGF-β 信号传导和上皮-间质转化。在小鼠模型中,它能够抑制 SIX1 介导的乳腺癌转移。 | |||
T12080 |
MLS000544460
|
Phosphatase | Metabolism |
MLS000544460 是一种高选择性和可逆的 Eya2 磷酸酶抑制剂(Kd:2.0 μM,IC50:4 μM)。MLS000544460 对 Eya2 磷酸酶介导的细胞迁移具有抑制作用且具有抗癌活性。 | |||
T12194 |
NCGC00249987
|
Others | Others |
NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of inhibitor of Eya2(Eya2 ED and MBP-Eya2 FL with IC50s of 3 μM and 6.9 μM ). |