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Cat. No.	Product Name	Target	Signaling Pathways
T78190	ERK1/2 inhibitor 9	ERK	MAPK
	ERK1/2 inhibitor 9 (Probe 1)为共价ERK1/2抑制剂，具备亚微摩尔级别的细胞活性(A375 GI50=0.47 μM)，能够下调磷酸化ERK1/2。通过与反式环辛烯(TCO)标记的Tz-Thalidomide相结合，ERK1/2 inhibitor 9可形成ERK-CLIPTAC，进而触发ERK1/2的降解。
T79808	KRAS G12C inhibitor 61	ERK	MAPK
	KRAS G12C inhibitor 61 (Example 3) 在 MIA PaCa-2 细胞中抑制 ERK1/2 磷酸化，其 IC50 为 9 nM。此化合物适用于胰腺癌、结直肠癌和肺癌的研究。
T69383	NBI-42902
	NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(i) = 0.56 nm). Tritiated NBI-42902 binds with high affinity (K(d) = 0.19 nm) to a single class of binding sites and can be displaced by a range of peptide and nonpeptide GnRH receptor ligands. In vitro experiments demonstrate that NBI-42902 is a potent functional, competitive antagonist of GnRH stimulated IP accumulation, Ca(2+) flux, and ERK1/2 activation. It did not stimulate histamine release from rat...