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Cat. No.	Product Name	Target	Signaling Pathways
T64147	ERK1/2 inhibitor 6
	ERK1/2 inhibitor 6 是 ERK1/2 的有效抑制剂。其中丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中发挥着极大的作用，而细胞外信号调节激酶 (ERK) 是 MAPK 家族的成员。ERK1/2 inhibitor 6 对癌症、炎症或其他增殖性疾病表现出研究或预防的潜力。
T63229	ITK inhibitor 6
	ITK inhibitor 6 是选择性的、有效的 ITK 抑制剂，能够作用于 ITK (IC50: 4 nM)、BTK (IC50: 133 nM)、JAK3 (IC50: 320 nM)、EGFR (IC50: 2360 nM)、LCK (IC50: 155 nM)。ITK inhibitor 6 对 PLCγ1 和 ERK1/2 的磷酸化具有抑制作用，表现出抗增殖效果。
T79047	MEK-IN-6	ERK	MAPK
	MEK-IN-6（Example 69）是一种针对MEK的抑制剂，在A375细胞中有效抑制ERK1/2（THR202/Tyr204）的磷酸化，其IC50值为2 nM。此化合物主要应用于癌症研究领域。
T36676	Rineterkib hydrochloride
	Rineterkib hydrochloride (compound B) is an orally active RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer[1]. ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the C...
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...