Cat. No. | Product Name | Target | Signaling Pathways |
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T37431 |
ENPP1 Inhibitor C
ENPP1 Inhibitor C |
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ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 activity in MDA-MB-231 human breast and C6 rat glioma cancer cells when used at a concentration of 10 μM. |1. Kawaguchi, M., Han, X., Hisada, T., et al. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging, and prognostic assessment of malignant brea... | |||
T69560 |
ENPP1 inhibitor 43
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ENPP1 inhibitor 43 is a novel small molecule for cancer immunotherapy. | |||
T60105 |
Enpp-1-IN-14
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PDE | Metabolism |
Enpp-1-IN-14 是有效的外核苷酸焦磷酸酶/磷酸二酯酶 (ENPP1) 抑制剂,对重组人 ENPP-1 的 IC50 为 32.38 nM。Enpp-1-IN-14具有抗肿瘤活性。 | |||
T78169 |
Enpp-1-IN-16
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PDE | Metabolism |
Enpp-1-IN-16 是一种靶向 ENPP1 的抑制剂,具有潜在的抗癌症活性。Enpp-1-IN-16 可用于研究胰岛素抵抗与II型糖尿病和软骨钙化病和骨关节炎类由 ENPP1介导的各类疾病。 | |||
T61136 | Enpp-1-IN-11 | ||
Enpp-1-IN-11 (compound 23) is a highly potent inhibitor of Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1), with a Ki value of 45 nM. It demonstrates excellent stability in human and mouse plasma and exhibits low clearance in both human and mouse liver microsomes. Enpp-1-IN-11 holds promise for anticancer research [1]. | |||
T37832 |
CAY10761
CAY10761 |
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CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 |1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p... | |||
T61514 | Enpp-1-IN-12 | ||
Enpp-1-IN-12 (化合物 43) 是一种有效和具有口服活性的外核苷酸焦磷酸酶/磷酸二酯酶 1 (ENPP1) 抑制剂,Ki 值 41 nM。Enpp-1-IN-12 具有抗肿瘤活性。 | |||
T60669 | Enpp-1-IN-10 | ||
Enpp-1-IN-10 (compound 1) 是可用于抗癌研究的,外核苷酸焦磷酸酶-磷酸二酯酶 1 (ENPP1)的有效抑制剂,Ki 值为 3.866 μM。 | |||
T63535 |
Enpp-1-IN-13
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Enpp-1-IN-13 是外核苷酸焦磷酸酶/磷酸二酯酶(ENPP)抑制剂,能够作用于 ENPP1 (IC50: 1.29 μM) 和 ENPP3 (IC50: 20.2 μM),表现出抗癌作用。 | |||
T79032 | Enpp-1-IN-17 | ||
Enpp-1-IN-17 (example 274) 是一种ENPP1抑制剂,其对cGAMP水解的Ki值在100 nM-1 μM范围内,而对ATP水解的Ki值则大于1 μM。该化合物在抑制cGAMP水解方面相对于ATP水解的选择性比率超过6.4。 | |||
T36133 |
3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
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3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; Ki = 50 μM).1,2 It also inhibits urease (IC50 = 84.53 μM for the Jack bean enzyme).3 |1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities. Bioorg. Med. Chem. 14(23), 8066-8072 (2006).|2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, ... | |||
T61860 |
Enpp-1-IN-9
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Enpp-1-IN-9, a powerful inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1), exhibits wide substrate specificity, capable of cleaving various bonds such as phosphodiester bonds of nucleotides and nucleotide sugars, as well as pyrophosphate bonds of nucleotides and nucleotide sugars. Its potential application lies in the fields of cancer and infectious disease research[1]. |