首页工具

搜索结果

Search Results for " egfr-in-82 "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T78788	EGFR-IN-82	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-82（化合物8a）是一种口服活性的EGFR抑制剂，显示出对EGFRL858R/T790M/C797S的IC50为0.09 nM，以及对EGFRDel19/T790M/C797S的IC50为0.06 nM的高选择性，而对EGFRWT的抑制作用不明显。此化合物具备显著的抗增殖能力，并能有效抑制肿瘤增长，常用于非小细胞肺癌（NSCLC）的研究。
T72890	VEGFR-2-IN-30
	VEGFR-2-IN-30为一种针对VEGFR-2的抑制剂（IC50：66 nM），同时对PDGFR、EGFR及FGFR1亦有一定抑制作用，其IC50s分别为180、98、82 nM。此外，VEGFR-2-IN-30能够阻止癌细胞在S期的进展并诱导早期以及晚期的细胞凋亡（apoptosis）。
T37594	Pericosine A
	Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t...