Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17876 |
E3 ligase Ligand 18
|
Others | Others |
E3 ligase Ligand 18 is a ligand that binds to E3 ubiquitin ligase, and it can be chemically attached to a protein ligand through a linker to create PROTACs. The resulting PROTACs function as inducers of ubiquitination-mediated degradation, targeting cancer-promoting proteins[1]. | |||
T15189 |
Thalidomide-O-amido-C4-N3
E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) 是一种 E3 连接酶配体- linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 linker。 | |||
T83933 | CST 905 | ||
CST 905是一种强效且选择性的BRAFV600EDegrader (PROTAC)(DC50= 18 nM)。CST 905由连接到PLX衍生配体的von Hippel Lindau (VHL) E3连接酶配体及其链接器组成。与其他BRAFV600EDegraders不同,CST 905不激活ERK。 |