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Cat. No.	Product Name	Target	Signaling Pathways
T17871	E3 ligase Ligand 13	Others	Others
	E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) 是一种合成的 E3 连接酶配体- linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 linker。
T17897	cIAP1 Ligand-Linker Conjugates 13 E3 ligase Ligand-Linker Conjugates 43	Others	Others
	cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1].
T17904	Pomalidomide-PEG1-C2-N3 E3 ligase Ligand-Linker Conjugates 50,Cereblon Ligand-Linker Conjugates 13	Others	Others
	Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].
T17913	(S,R,S)-AHPC-PEG2-N3 VHL Ligand-Linker Conjugates 6,VH032-PEG2-N3,E3 ligase Ligand-Linker Conjugates 13	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG2-N3 (VHL Ligand-Linker Conjugates 6) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T40031	Thalidomide-O-C6-NH2 hydrochloride 4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride,萨力多胺-O-C6-氨基盐酸盐	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) 是一种合成的E3 连接酶配体 -linker 偶联物，用于 PROTAC dTAG-13 的合成。其中 dTAG-13 是一种 FKBP12F36V 和 BET 的降解剂。
T31221	dBRD9 dBRD-9,dBRD 9	PROTACs	PROTAC
	dBRD9是一种 PROTAC。dBRD9是一种双重作用的分子，一部分连接 Bromodomain-containing protein 9 （BRD9）的溴域，另一部分招募小脑 E3泛素连接酶的配体（ligand that recruits the cereblon E3 ubiquitin ligase）。dBRD9对 MOLM-13细胞中 BRD9具有抑制作用，可使其降解，IC50为104 nM。
T31221L	dBRD9 HCl dBRD9 HCl(2170679-45-3 Free base)	Epigenetic Reader Domain	Chromatin/Epigenetic
	dBRD9 HCl 是一种PROTAC，包含cereblon E3连接酶配体与BRD9抑制剂BI 7273。dBRD9 HCl 是有效和选择性的BRD9降解剂，在MOLM-13细胞中IC50的为56.6nM。dBRD9 HCl 在浓度高达5μM 时不会降解BRD4或BRD7。dBRD9 HCl 在人AML 细胞系中显示出抗增殖作用。
T18825	Thalidomide-O-C6-NH2	Others	Others
	Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].
T18824	Thalidomide-O-C6-NH2 TFA	Others	Others
	Thalidomide-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].
T36281	VH 032 amide-alkylC5-amine VH 032 amide-alkylC5-amine
	Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 13 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.