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Search Results for " duocarmycin "

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Cat. No.	Product Name	Target	Signaling Pathways
T11120	Duocarmycin TM	DNA Alkylation; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Duocarmycin TM 是一种有抗肿瘤活性的抗生素，也是一种 DNA 烷化剂。
T11119	Duocarmycin DM free base Duocarmycin	Others	Others
	Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.
T11118	Duocarmycin SA	Others	Others
	Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.
T11117	Duocarmycin MB	Others	Others
	Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T15180	Duocarmycin A	Caspase	Apoptosis; Proteases/Proteasome
	Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
T18324	MC-Val-Cit-PAB-duocarmycin chloride MC-Val-Cit-PAB-duocarmycin	Others	Others
	MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.
T11116	Duocarmycin MA	Others	Others
	Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T19300	Duocarmycin Analog	DNA Alkylation	DNA Damage/DNA Repair
	Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T11115	Duocarmycin GA	Others	Others
	Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance.
T12813L	Seco-Duocarmycin SA	DNA Alkylation	DNA Damage/DNA Repair
	Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T12875	Seco-Duocarmycin TM	Others	Others
	Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).
T12813	(S)-Seco-Duocarmycin SA	Others	Others
	(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates.
T73948	Duocarmycin DM
	Duocarmycin DM，一种DNA小沟烷基化剂（DNA minor-groove alkylator），作为抗体活性分子结合物（ADCs）的毒素，因其独特结构显示出抗癌活性。
T17982	Fmoc-Val-Cit-PAB-Duocarmycin TM	Others	Others
	Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB.
T63523	Duocarmycin analog-2
	Duocarmycin analog-2 是有效的 DNA 烷基化剂，表现出抗肿瘤作用，能够用于免疫偶联物的合成。
T18293	Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA	Others	Others
	Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker that incorporates the antitumor antibiotic Duocarmycin SA, connected through the Mal-PEG4-VC-PAB-DMEA-Seco linker, for targeted cancer therapy.
T70462	Pibrozelesin
	Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
T38611	Seco-DUBA
	Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).

化合物

Duocarmycin TM

Cat.No: T11120

Target: DNA Alkylation, Antibiotic

Duocarmycin DM free base

Cat.No: T11119

Synonym: Duocarmycin

Target: Others

Duocarmycin SA

Cat.No: T11118

Target: Others

Duocarmycin MB

Cat.No: T11117

Target: Others

Duocarmycin A

Cat.No: T15180

Target: Caspase

MC-Val-Cit-PAB-duocarmycin chloride

Cat.No: T18324

Synonym: MC-Val-Cit-PAB-duocarmycin

Target: Others

Duocarmycin MA

Cat.No: T11116

Target: Others

Duocarmycin Analog

Cat.No: T19300

Target: DNA Alkylation

Duocarmycin GA

Cat.No: T11115

Target: Others

Seco-Duocarmycin SA

Cat.No: T12813L

Target: DNA Alkylation

Seco-Duocarmycin TM

Cat.No: T12875

Target: Others

(S)-Seco-Duocarmycin SA

Cat.No: T12813

Target: Others

Duocarmycin DM

Cat.No: T73948

Fmoc-Val-Cit-PAB-Duocarmycin TM

Cat.No: T17982

Target: Others

Duocarmycin analog-2

Cat.No: T63523

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA

Cat.No: T18293

Target: Others

Cat.No: T70462

Cat.No: T38611

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