Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15098 |
Deruxtecan
|
Others | Others |
Deruxtecan 是一种 ADC 药物-接头偶联物,由 DX-8951 (DXd) 的衍生物和马来酰亚胺-GGFG 肽接头组成,用于合成 DS-8201 和 U3-1402。 | |||
T18867 |
Val-Cit-PAB-MMAE
|
||
Val-Cit-PAB-MMAE 是 ADC 的药物-接头偶联物。它包含 ADC 接头(肽 Val-Cit-PAB)和有效的微管蛋白抑制剂 MMAE。 | |||
T17983 |
Fmoc-Val-Cit-PAB-MMAE
|
Others | Others |
Fmoc-Val-Cit-PAB-MMAE 由 ADC 接头 (Fmoc-Val-Cit-PAB) 和强效微管蛋白抑制剂 (MMAE) 组成。 它是一种用于 ADC 的药物-接头偶联物。 | |||
T16031 |
McMMAF
Maleimidocaproyl monomethylauristatin F |
Microtubule Associated | Cytoskeletal Signaling |
McMMAF 是一种保护基团共轭的 MMAF。它是一种具有马来酰亚胺基己酰基接头(MC 接头)的 MMAF 衍生物, MMAF 是一种有效的微管蛋白聚合抑制剂。它可与抗体或其他蛋白质或生物聚合物结合。 | |||
T4232 |
VCMMAE
mc-vc-PAB-MMAE |
Microtubule Associated | Cytoskeletal Signaling |
VCMMAE (mc-vc-PAB-MMAE) 是一种用于 ADC 的药物-接头偶联物,具有抗癌活性,它由 MMAE 和 Vc 连接而成。 | |||
T12573 |
Vipivotide tetraxetan
PSMA-617 |
Others | Others |
Vipivotide tetraxetan (PSMA-617) 是一种高效的前列腺特异性膜抗原抑制剂,其Ki 值为 0.37 nM。 | |||
T16899 |
SMCC-DM1
DM1-SMCC |
Others | Others |
SMCC-DM1 (DM1-SMCC) 是一种药物-接头偶联物,由有效的微管破坏剂 DM1 和接头 SMCC 组成,用于制备抗体药物偶联物。 | |||
T11917 |
Lys-SMCC-DM1
Lys-Nε-MCC-DM1 |
Microtubule Associated | Cytoskeletal Signaling |
DM1 是一种微管蛋白抑制剂。 Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) 是 DM1 的活性代谢物。 | |||
T18312 |
Mc-MMAE
Maleimidocaproyl-monomethylauristatin E,马来酰亚胺基己酰-单甲基澳瑞他汀 E |
Microtubule Associated | Cytoskeletal Signaling |
Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) 是保护基团 (马来酰亚氨基己酰) 与 MMAE 共轭连接得到的化合物。它是微管蛋白抑制剂,可用于偶联抗体。 | |||
T17731 |
CL2A-SN-38
|
Others | Others |
CL2A-SN-38 是一种药物-接头偶联物,由一种有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成,用于制造抗体药物偶联物。它对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。 | |||
T17977 |
Fmoc-PEA
|
||
Fmoc-PEA 是一种可降解的抗体偶联药物 (ADC)的linker。 | |||
T17654 |
Boc-NH-C6-Br
N-BOC-6-溴代己胺 |
Others | Others |
Boc-NH-C6-Br 是一种可切割的 ADC 接头,用于合成抗体-药物偶联物。 | |||
T14746 |
Boc-NH-PEG4-CH2COOH
N-叔丁氧羰基-四聚乙二醇-乙酸 |
PROTAC Linker | PROTAC |
Boc-NH-PEG4-CH2COOH 是一种可切割的 ADC 接头,用作抗体-药物偶联物的接头。它也是基于 PEG 的 PROTAC 接头,可用于 PROTAC 的合成。 | |||
T18308 |
MC-Gly-Gly-Phe
|
||
MC-Gly-Gly-Phe 是一种用于抗体-药物偶联物的可切割接头。 | |||
T18479 |
NH-bis(C1-Boc)
亚氨基二乙酸二异丁酯 |
Others | Others |
Boc-NH-C6-Br 是一种不可切割的接头,用于抗体-药物偶联物。 | |||
T18870 |
Vc-MMAD
|
Others | Others |
Vc-MMAD 由 linker (Val-Cit) 和微管抑制剂 MMAD 组成。Vc-MMAD 可用于偶联抗体。 | |||
T9282 |
DBCO-C3-Acid
DBCO-ACID |
Others | Others |
DBCO-(CH2)3-Acid 是一种用于抗体-药物偶联物的 Click Chemistry 中间体,可用以合成 ADC linker。 | |||
T3503 |
MC-Val-Cit-PABC-PNP
Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate,马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇 对硝基苯基碳酸脂 |
Others; AChR | Neuroscience; Others |
MC-Val-Cit-PABC-PNP 是一种组织蛋白酶可裂解的 ADC 肽接头,可用于合成抗体偶联药物。 | |||
T4286 |
Fmoc-Val-Ala-PAB-OH
Fmoc-Val-Ala-PAB |
Others; AChR | Neuroscience; Others |
Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) 是一种有用的接头,可用于制备用于靶向药物递送的抗体-药物偶联物。它还用于合成带有溶酶体可切割接头的 RGD 拟肽-紫杉醇缀合物。 | |||
T18540 |
Phe-Lys(Trt)-PAB
|
Others | Others |
Phe-Lys(Trt)-PAB 是一种组织蛋白酶可裂解的 ADC 接头,用于合成抗体-药物偶联物。 | |||
T18718 |
SPP-DM1
|
Others | Others |
SPP-DM1, a drug-linker conjugate for antibody-drug conjugates (ADC), demonstrates potent antitumor activity. It comprises DM1 (a potent microtubule-disrupting agent) connected through the ADC linker SPP[1]. | |||
T18309 |
Mc-Leu-Gly-Arg
|
Others | Others |
Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design. | |||
T18700 |
SPB
|
Others | Others |
SPB is a potent anti-inflammatory drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Xanthotoxol connected through the ADC linker. | |||
T39111 | Fmoc-D-Trp(Boc)-OH | ||
Fmoc-D-Trp(Boc)-OH is a labile ADC linker employed for synthesizing antibody-drug conjugates (ADCs). | |||
T17337 |
4-N3Pfp-NHS ester
|
Others | Others |
4-N3Pfp-NHS ester is a noncleavable ADC linker utilized for synthesizing antibody-drug conjugates (ADCs). | |||
T41074 |
MB-VC-MGBA
|
||
MB-VC-MGBA is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), utilizing the minor-groove-binding DNA-alkylating agent (MGBA), connected through the ADC linker MB-VC. | |||
T38493 |
MCC-DM1
MCC-DM1 |
||
MCC-DM1 is a drug-Linker Conjugates for ADC such ad Anti-CD22-MCC-DM1. | |||
T18310 |
AZ1508
MC-Lys-MMETA |
Others | Others |
AZ1508, a tubulin inhibitor[1], serves as a drug-linker conjugate for antibody-drug conjugates (ADC) targeting breast and stomach cancer treatment. | |||
T18799 | Tetrazine-Ph-OPSS | Others | Others |
Tetrazine-Ph-OPSS is an ADC linker employed for synthesizing ADCs, or antibody-drug conjugates [1]. | |||
T18315 |
MC-Sq-Cit-PAB-Dolastatin10
|
Others | Others |
MC-Sq-Cit-PAB-Dolastatin10 is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Dolastatin10 (a tubulin polymerization inhibitor) connected through the MC-Sq-Cit-PAB ADC linker. | |||
T18511 |
OPSS-Val-Cit-PAB-OH
|
Others | Others |
OPSS-Val-Cit-PAB-OH is an ADC linker utilized for the synthesis of antibody-drug conjugates (ADCs) [1]. | |||
T18330 |
MC-Val-Cit-PAB-vinblastine
|
Others | Others |
MC-Val-Cit-PAB-vinblastine is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), featuring vinblastine (a microtubule protein inhibitor) connected through the MC-Val-Cit-PAB ADC linker. | |||
T14053 |
5-Maleimidovaleric acid
|
Others | Others |
5-Maleimidovaleric acid, a cleavable linker for antibody-drug conjugates (ADCs) synthesis, is employed as an ADC linker[1]. | |||
T18320 |
MC-Val-Cit-PAB-carfilzomib iodide
MC-Val-Cit-PAB-carfilzomib |
Others | Others |
MC-Val-Cit-PAB-carfilzomib is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), comprising the irreversible proteasome inhibitor carfilzomib, connected through the ADC linker MC-Val-Cit-PAB. | |||
T16880 |
SIA Crosslinker
|
Others | Others |
SIA Crosslinker is a non-cleavable ADC linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T18358 | Methyltetrazine-SS-NHS | Others | Others |
Methyltetrazine-SS-NHS is a cleavable ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T18246 |
Mal-C2-Gly3-EDA-PNU-159682
|
Others | Others |
Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), combines the cleavable ADC linker Mal-C2-Gly3-EDA with the potent ADC cytotoxin PNU-159682. | |||
T17150 | Tr-PEG3-OH | Others | Others |
Tr-PEG3-OH is a non-cleavable, three-unit PEG ADC linker employed for ADC synthesis, specifically in the context of antibody-drug conjugates (ADCs). | |||
T15322 | Fmoc-NH-PEG8-CH2CH2COOH | Others | Others |
Fmoc-NH-PEG8-CH2CH2COOH is a cleavable linker employed for ADC synthesis, primarily in the formation of antibody-drug conjugates (ADCs)[1]. | |||
T14771 |
Br-PEG4-C2-Boc
|
Others | Others |
Br-PEG4-C2-Boc is a cleavable 4-unit PEG ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T39164 |
MC-betaglucuronide-MMAE-1
|
||
MC-betaglucuronide-MMAE-1 is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADCs), employing MMAE (a tubulin polymerization inhibitor) connected through the cleavable ADC linker MC-betaglucuronide. | |||
T82540 |
DL-01
|
||
DL-01 为 ADC 用途的活性分子-连接子偶联物(drug-linker conjugates for ADC),适合于 ADC 合成。 | |||
T18327 |
MC-Val-Cit-PAB-Retapamulin
|
Others | Others |
MC-Val-Cit-PAB-Retapamulin is a drug-linker conjugate for antibody-drug conjugates (ADC) that exhibits potent antitumor activity. This compound utilizes Retapamulin, a ribosome inhibitor, connected through the ADC linker MC-Val-Cit-PAB. | |||
T14752 | Boc-NH-PEG6-CH2CH2COOH | Others | Others |
Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[1]. | |||
T18724 |
Sulfo-DMAC-SPP
|
Others | Others |
Sulfo-DMAC-SPP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs) [1]. | |||
T18316 |
MC-Sq-Cit-PAB-Gefitinib
|
Others | Others |
MC-Sq-Cit-PAB-Gefitinib is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Gefitinib—an EGFR tyrosine kinase inhibitor—connected through the MC-Sq-Cit-PAB ADC linker. | |||
T17985 |
Gemcitabine-O-Si(di-iso)-O-Mc
|
Others | Others |
Gemcitabine-O-Si(di-iso)-O-Mc, a drug-linker conjugate for Antibody-Drug Conjugates (ADC), exhibits potent antitumor activity. It incorporates Gemcitabine, a pyrimidine nucleoside analog antimetabolite and antineoplastic agent, connected through the ADC linker[1]. | |||
T18331 |
MC-VC-PABC-DNA31
|
Others | Others |
MC-VC-PABC-DNA31 is a drug-linker conjugate designed for Antibody-Drug Conjugates (ADC) that demonstrates potent antitumor activity. It employs DNA31, an effective inhibitor of RNA polymerase, connected through the MC-VC-PABC ADC linker. | |||
T41130 |
Bis-SS-C3-sulfo-NHS ester
Bis-SS-C3-sulfo-NHS ester |
||
Bis-SS-C3-sulfo-NHS ester is a cleavable ADC linker employed for the synthesis of antibody-drug conjugates (ADCs). | |||
T17811 | DBCO-SS-aldehyde | Others | Others |
DBCO-SS-aldehyde is an ADC linker employed for ADC synthesis[1]. This cleavable linker is designed to facilitate the conjugation of antibodies and drugs, resulting in antibody-drug conjugates (ADCs). |