Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11249 |
Exatecan
依喜替康,DX-8951,DX-8951f |
Topoisomerase | DNA Damage/DNA Repair |
Exatecan (DX-8951f) 是一种 DNA 拓扑异构酶 I (TOP1) 抑制剂,IC50 值为 2.2 μM (0.975 μg/mL)。Exatecan 具有抗肿瘤活性,可用于癌症研究。 | |||
T78630 |
Exatecan mesylate dihydrate
DX-8951 mesylate dihydrate |
Topoisomerase | DNA Damage/DNA Repair |
Exatecan (DX-8951) mesylate dihydrate 是 DNA topoisomerase I 抑制剂,其 IC50 为 2.2 μM (0.975 μg/mL),用于癌症研究。 | |||
T16024 |
MC-GGFG-DX8951
|
Others | Others |
MC-GGFG-DX8951 is a drug-linker conjugate designed for antibody-drug conjugation (ADC) that demonstrates antitumor activity through the deployment of DX8951, a DNA topoisomerase I inhibitor, connected using the protease-cleavable MC-GGFG linker[1]. | |||
T77847 |
MC-Val-Cit-PAB-Exatecan
MC-Val-Cit-PAB-DX8951 |
||
MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) 是一种抗体-活性分子偶联物(ADC)的关键部分,由 DNA 拓扑异构酶 I 抑制剂 DX-8951 和组织蛋白酶敏感的连接子共同构成。 | |||
T15098 |
Deruxtecan
|
Others | Others |
Deruxtecan 是一种 ADC 药物-接头偶联物,由 DX-8951 (DXd) 的衍生物和马来酰亚胺-GGFG 肽接头组成,用于合成 DS-8201 和 U3-1402。 | |||
T77901 |
Ac-Exatecan
|
Topoisomerase | DNA Damage/DNA Repair |
Ac-Exatecan是经乙酰化改良的Exatecan,后者(DX-8951)为ADC生产中普遍使用的毒素组分(ADC Cytotoxin),同时作为DNA拓扑异构酶I(topoisomerase I)的抑制剂,其IC50值为2.2 μM。 |