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24

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19080	DOPE 1,2-二油酰-SN-甘油-3-磷酰乙醇胺	Others	Others
	DOPE (DOPE) 是一种阳离子脂质体的中性辅助脂质 (helper lipid)，能够与阳离子磷脂结合，增强裸 siRNA 的转染效率。
T74882	DOPE-GA
	DOPE-GA 可用于制备脂质体，用于药物递送的研究。
T74883	DOPE-NHS
	DOPE-NHS是一种连接子，用于多肽与外泌体或其他可能的基于膜的纳米颗粒的结合，适用于药物递送。
T77276	DOPE-mPEG (MW 2000)
	DOPE-mPEG (MW 2000)，一种磷脂多分散PEG（亦称DOPE脂质体），广泛应用于制备靶向给药脂质体及巨大单层囊泡(GUVs)。此化合物能显著降低脂质体对pH的敏感性，其作用具浓度依赖性。
T35606	1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium 1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)
	1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium (1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)) 可与 DOPC 和 DOPE 一起用于脂质混合物中，作为有效的无毒和非病毒 DNA 载体。 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium 已用于单层囊泡的形成，以研究曲率对膜结构的影响，并用于支持脂质双层的形成，以研究各种支持膜小叶之间脂质重新分布的材料。
T11318	Dopexamine hydrochloride 盐酸多培沙明,FPL60278AR	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dopexamine hydrochloride (FPL60278AR) 是β2肾上腺素能受体激动剂。
T9409	Mesdopetam hemitartrate IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Mesdopetam hemitartrate (IRL790 hemitartrate) 是一种多巴胺D3受体拮抗剂 (Ki=90 nM;IC50=9.8 μM)，具有稳定精神运动的作用，可用于帕金森病的运动和精神并发症的研究。
T4506	Gadopentetate dimeglumine Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt	Others	Others
	Gadopentetate dimeglumine (Gd-DTPA) 可用于核磁共振成像 (MRI) 中，使血管、器官和其他非骨组织能够更清晰地被看到。
T19332	Gadopentetic acid gadolinium complex,钆喷酸,Gd-DTPA	Others	Others
	Gadopentetic acid (gadolinium complex) 是一种顺磁性造影剂，通常通过静脉内注射 (i.v.) 的方式用于 DCE-MRI 研究。
T8653	DOPEXAMINE	Dopamine Receptor	GPCR/G Protein; Neuroscience
	DOPEXAMINE 是一种多巴胺能激动剂。
T12546	Prolyl Endopeptidase Inhibitor 1 (Boc)-Prolyl-prolinal,BPP,Boc-Pro-prolinal	Others	Others
	Prolyl Endopeptidase Inhibitor 1 is a potent inhibitor of prolyl endopeptidase (PEP; PE)(Ki : 15 nM) , has anti-amnesic effect.
T64726	tert-Butyl 5-iodopentanoate
	tert-Butyl 5-iodopentanoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64726，CAS号为 56198-37-9。
T124545	Pseudopelletierine hydrochloride
	Pseudopelletierine hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124545。
T21094	Pseudopelletierine free base NSC 116056,Granatonine,Pseudopelletierine,Granatan-3-one
	Pseudopelletierine is the main alkaloid derived from the root-bark of Punica granatum, along with at least three other alkaloids: isopelletierine, methylpelleteirine (C9H17ON) and pelletierine, which yield 1.8, 0.01, 0.20 and 0.52 grams per kilogram of ra
T29566	Acetamide, N-(5-amino-2-((5-phthalimidopentyl)oxy)benzyl)-
	Acetamide, N-(5-amino-2-((5-phthalimidopentyl)oxy)benzyl)- is a bioactive chemical.
T36181	Quinaldopeptin
	Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1 and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).
T30331	Benzamide, 5-amino-2-((5-phthalimidopentyl)oxy)-
	Benzamide, 5-amino-2-((5-phthalimidopentyl)oxy)- is a bioactive chemical.
T64439	tert-Butyl 5-iodopentylcarbamate
	tert-Butyl 5-iodopentylcarbamate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64439。
T38828	Mesdopetam IRL790
	Mesdopetam (IRL790) is a dopamine D3 receptor antagonist with a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It exhibits psychomotor stabilizing properties and is utilized in the study of motor and psychiatric complications associated with Parkinson's disease.
T37027	MHAPC-Chol
	MHAPC-Chol is a cationic cholesterol. MHAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in MHAPC-chol accumulation in the liver.
T37017	OH-C-Chol
	OH-C-Chol is a cationic cholesterol derivative. OH-C-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver.
T37586	DMHAPC-Chol
	DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 μM. DMHAPC-Chol, as part of a lipoplex with DOPE , has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to delive...
T37035	HAPC-Chol
	HAPC-Chol is a cationic cholesterol. HAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in HAPC-chol accumulation in the lungs.
T37018	OH-Chol
	OH-Chol is a cationic cholesterol derivative.1 OH-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intrat...

化合物

Cat.No: T19080

Synonym: 1,2-二油酰-SN-甘油-3-磷酰乙醇胺

Target: Others

Cat.No: T74882

Cat.No: T74883

DOPE-mPEG (MW 2000)

Cat.No: T77276

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium

Cat.No: T35606

Synonym: 1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)

Dopexamine hydrochloride

Cat.No: T11318

Synonym: 盐酸多培沙明,FPL60278AR

Target: Adrenergic Receptor

Mesdopetam hemitartrate

Cat.No: T9409

Synonym: IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)

Target: Dopamine Receptor

Gadopentetate dimeglumine

Cat.No: T4506

Synonym: Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt

Target: Others

Gadopentetic acid

Cat.No: T19332

Synonym: gadolinium complex,钆喷酸,Gd-DTPA

Target: Others

Cat.No: T8653

Target: Dopamine Receptor

Prolyl Endopeptidase Inhibitor 1

Cat.No: T12546

Synonym: (Boc)-Prolyl-prolinal,BPP,Boc-Pro-prolinal

Target: Others

tert-Butyl 5-iodopentanoate

Cat.No: T64726

Pseudopelletierine hydrochloride

Cat.No: T124545

Pseudopelletierine free base

Cat.No: T21094

Synonym: NSC 116056,Granatonine,Pseudopelletierine,Granatan-3-one

Acetamide, N-(5-amino-2-((5-phthalimidopentyl)oxy)benzyl)-

Cat.No: T29566

Cat.No: T36181

Benzamide, 5-amino-2-((5-phthalimidopentyl)oxy)-

Cat.No: T30331

tert-Butyl 5-iodopentylcarbamate

Cat.No: T64439

Cat.No: T38828

Synonym: IRL790

Cat.No: T37027

Cat.No: T37017

Cat.No: T37586

Cat.No: T37035

Cat.No: T37018

Cat. No.	Product Name	Target	Signaling Pathways
T2931	2-Amino-5-ureidopentanoic acid DL-Citrulline,Citrulline,瓜氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-5-ureidopentanoic acid (Citrulline) 存在于肝脏中，不是蛋白质的构成成分，为人体脲循环的一个重要中间物，可与鸟氨酸、精氨酸合用治疗高氨血症。
T75623	Sadopeptins A
	Sadopeptins A 是一种天然产物，可以从 Streptomycessp 中分离出来。Sadopeptins A 是一种有效的蛋白酶体抑制剂。
TN4314	Isonardoperoxide	Antifection	Microbiology/Virology
	Isonardoperoxide shows strong antimalarial activity against Plasmodium falciparum malaria (6.0 × 10-7 M).
T75624	Sadopeptins B
	Sadopeptins B 是一种天然产物，可以从 Streptomycessp 中分离出来。Sadopeptins B 是一种有效的蛋白酶体抑制剂。

天然产物

2-Amino-5-ureidopentanoic acid

Cat.No: T2931

Synonym: DL-Citrulline,Citrulline,瓜氨酸

Target: Others, Endogenous Metabolite

Cat.No: T75623

Isonardoperoxide

Cat.No: TN4314

Target: Antifection

Cat.No: T75624

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