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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7180	Sultopride hydrochloride LIN-1418 hydrochloride,盐酸舒托必利,盐酸舒必利	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Sultopride hydrochloride (LIN-1418 hydrochloride) 是一种多巴胺 D2受体的选择性拮抗剂。
T5678	Lazabemide hydrochloride N-(2-Aminoethyl)-5-chlor-2-pyridincarbox,拉扎贝胺盐酸盐	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) 是一种单胺氧化酶 B 的选择性的可逆抑制剂，但对 MAO-A 活性较低。它在高浓度时，具有抑制单胺摄取的作用，抑制去甲肾上腺素、血清素和多巴胺摄取。它可用于研究帕金森和阿尔茨海默病。
T5470	LAZABEMIDE 拉扎贝胺,Ro 19-6327	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Lazabemide (Ro 19-6327) 是一种单胺氧化酶 B 的选择性的可逆抑制剂，但对 MAO-A 活性较低。它高浓度时具有抑制单胺摄取的作用，能够抑制去甲肾上腺素、血清素和多巴胺摄取，其IC50值分别为 86 μM、123 μM 和 >500 μM。它可用于研究帕金森和阿尔茨海默病。
T126370	Dopacetamide
	Dopacetamide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126370，CAS号为 1129-53-9。
T12483	Piperidine-MO-1	Others	Others
	Piperidine-MO-1是多巴胺受体 (dopamine receptor) 调节剂，在大鼠纹状体中增加DOPAC 的 ED50 值为68 μmol/kg。
T26997	CGP-28014
	CGP-28014 is an inhibitor of catechol-O-methyltransferase. CGP-28014 increases the renal excretion of both dopamine and dihydroxyphenylacetic acid (DOPAC) but does not affect renal sodium handling indicating a different mechanism of action. CGP-28014 sign
T37533	DOPAL
	DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as wel...

化合物

Sultopride hydrochloride

Cat.No: T7180

Synonym: LIN-1418 hydrochloride,盐酸舒托必利,盐酸舒必利

Target: Dopamine Receptor

Lazabemide hydrochloride

Cat.No: T5678

Synonym: N-(2-Aminoethyl)-5-chlor-2-pyridincarbox,拉扎贝胺盐酸盐

Target: MAO, Monoamine Oxidase

LAZABEMIDE

Cat.No: T5470

Synonym: 拉扎贝胺,Ro 19-6327

Target: MAO, Monoamine Oxidase

Cat. No.	Product Name	Target	Signaling Pathways
T4907	3,4-Dihydroxybenzeneacetic acid DOPAC,3,4-Dihydroxyphenylacetic acid,3,4-二羟基苯乙酸	Endogenous Metabolite	Metabolism
	3,4-Dihydroxybenzeneacetic acid (3,4-Dihydroxyphenylacetic acid) 是一种多巴胺的主要神经元代谢产物。