Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0310 |
Actarit
阿克他利,4-acetylaminophenylacetic acid |
Others | Others |
Actarit (4-acetylaminophenylacetic acid) 是一种口服具有活性的化合物,可用于抗风湿研究以及 II 型胶原诱导性关节炎的研究。 | |||
T7882 |
Indomethacin farnesil
吲哚美辛法呢酯,Infree |
Others; COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience; Others |
Indomethacin farnesil (Infree) 是具有口服活性的 Indomethacin 前药,可通过干扰溶酶体的正常功能来破坏自噬流,有抗炎和抗风湿作用。它是一种可透过血脑屏障的,非选择性的 COX1和 COX2抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 18 nM 和 26 nM。 | |||
T70718 |
CR-6086
|
||
CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct from the general effects of cyclooxygenase inhibitors. CR6086 showed selectivity and high affinity for the human EP4 receptor (Ki = 16.6 nM) and functioned as a pure antagonist (half-maximal inhibitory concentration, 22 nM) on PGE2-stimulated cAMP production. |