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Cat. No. Product Name Target Signaling Pathways
T0310 Actarit

阿克他利,4-acetylaminophenylacetic acid

Others Others
Actarit (4-acetylaminophenylacetic acid) 是一种口服具有活性的化合物,可用于抗风湿研究以及 II 型胶原诱导性关节炎的研究。
T7882 Indomethacin farnesil

吲哚美辛法呢酯,Infree

Others; COX; Autophagy Autophagy; Immunology/Inflammation; Neuroscience; Others
Indomethacin farnesil (Infree) 是具有口服活性的 Indomethacin 前药,可通过干扰溶酶体的正常功能来破坏自噬流,有抗炎和抗风湿作用。它是一种可透过血脑屏障的,非选择性的 COX1和 COX2抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 18 nM 和 26 nM。
T70718 CR-6086

CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct from the general effects of cyclooxygenase inhibitors. CR6086 showed selectivity and high affinity for the human EP4 receptor (Ki = 16.6 nM) and functioned as a pure antagonist (half-maximal inhibitory concentration, 22 nM) on PGE2-stimulated cAMP production.

化合物

Actarit
Cat.No: T0310
Synonym: 阿克他利,4-acetylaminophenylacetic acid
Target: Others
Indomethacin farnesil
Cat.No: T7882
Synonym: 吲哚美辛法呢酯,Infree
Target: Others, COX, Autophagy
CR-6086
Cat.No: T70718
Synonym:
Target:
TargetMol Loading
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