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Search Results for " dll4 "

Targets Recommended: Gamma-secretase

4

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76788	Demcizumab OMP 21M18	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Demcizumab (OMP 21M18) 是一种抗 DLL4 单克隆抗体。Demcizumab 是一种有效的 Notch 通路抑制剂。Demcizumab 在多种癌症模型中无论使单独还联合化疗试剂使用都是有效的。
T76871	Navicixizumab
	Navicixizumab (OMP-305B83) 是一种双特异性抗 VEGF 和抗 DLL4抑制抗体。Navicixizumab 可以与紫杉醇结合用于癌症研究。Navicixizumab 可用于卵巢癌、原发性腹膜癌或输卵管癌的研究。
T77157	Dilpacimab
	Dilpacimab (ABT165) 是一种有效的双可变结构域免疫球蛋白，靶向 delta 样配体 4 (DLL4) 和VEGF 通路。Dilpacimab 可用于癌症研究。
T80615	Enoticumab REGN421
	Enoticumab（REGN421，SAR153192）是一种针对人类Dll4的IgG1κ类型抗体。DLL4为Notch信号通路中的关键配体，其功能通过巨胞饮作用依赖的非转录调控机制影响长链脂肪酸的摄取。该抗体在卵巢癌异种移植模型中展示出明确的体内活性，其中EGN421（2.5mg/kg，周剂量）在小鼠皮下TOV-112D及腹膜内A2780人类肿瘤异种移植模型中实现了分别达到86%和83%的肿瘤生长抑制效果。

化合物

Cat.No: T76788

Synonym: OMP 21M18

Target: Gamma-secretase

Cat.No: T76871

Cat.No: T77157

Cat.No: T80615

Synonym: REGN421

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01337	DLL4 Protein, Mouse, Recombinant (His) Dll4,δ4,delta-like 4 (Dr...	Mouse	HEK293 Cells
	DLL4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.7 kDa and the accession number is Q9JI71.
TMPK-00360	DLL4 Protein, Human, Recombinant (His & Avi) notch ligand DLL4,MGC126344	Human	HEK293 Cells
	Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibit...
TMPY-01321	DLL4 Protein, Human, Recombinant (His) hδ2,Delta-like 4,δ-like 4,hdelta2,δ-like <...	Human	HEK293 Cells
	DLL4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.7 kDa and the accession number is Q9NR61.
TMPY-04803	DLL4 Protein, Human, Recombinant δ-like 4 (Drosophila),delta-like 4 (Drosop...	Human	HEK293 Cells
	DLL4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 55 kDa and the accession number is Q9NR61.
TMPY-05796	DLL4 Protein, Mouse, Recombinant (mFc) δ4,Dll4,delta-like 4 (Dr...	Mouse	HEK293 Cells
	DLL4 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 80.61 kDa and the accession number is Q9JI71.
TMPY-00776	DLL4 Protein, Human, Recombinant (hFc) δ-like 4 (Drosophila),Delta-like 4,hdelta2...	Human	HEK293 Cells
	DLL4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 81 kDa and the accession number is Q9NR61.
TMPY-05093	DLL4 Protein, Rhesus, Recombinant (His) delta-like 4 (Drosophila),δ-like 4 (Drosop...	Rhesus	HEK293 Cells
	DLL4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.1 kDa and the accession number is XP_001099250.1.
TMPY-06876	DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated hδ2,δ-like 4,Delta-like 4,δ-like 4	Human	HEK293 Cells
	DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.55 kDa and the accession number is NP_061947.1.

重组蛋白

DLL4 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01337

Species: Mouse

Expression System: HEK293 Cells

DLL4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00360

Species: Human

Expression System: HEK293 Cells

DLL4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01321

Species: Human

Expression System: HEK293 Cells

DLL4 Protein, Human, Recombinant

Cat.No: TMPY-04803

Species: Human

Expression System: HEK293 Cells

DLL4 Protein, Mouse, Recombinant (mFc)

Cat.No: TMPY-05796

Species: Mouse

Expression System: HEK293 Cells

DLL4 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00776

Species: Human

Expression System: HEK293 Cells

DLL4 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-05093

Species: Rhesus

Expression System: HEK293 Cells

DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06876

Species: Human

Expression System: HEK293 Cells

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