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Search Results for " dd2 "

Targets Recommended: Parasite

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T10903	CWHM-1552	Parasite	Microbiology/Virology
	CWHM-1552 是一种有效的恶性疟原虫抑制剂。对于 3D7 和 Dd2 菌株，IC50 分别为 51 nM 和 53 nM。
T10902	CWHM-1008	Others	Others
	CWHM-1008 is an effective oral antimalarial drug. The EC50 values of the drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains are 46 and 21 nM, respectively.
T12084	MMV008138	Others	Others
	MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM).
T35740	FR900098 (sodium salt)
	FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively). FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner. FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.
T60302	4,4'-Dicyanostilbene
	4,4'-Dicyanostilbene (化合物 43) 是一种有效的抗疟药，可抗 Dd2 菌株，EC50值为 27 nM。4,4'-Dicyanostilbene 对耐甲氧西林金黄色葡萄球菌具有体内功效。
T63456	Antimalarial agent 12
	Antimalarial agent 12 是有效的抗疟 (antimalarial) 药，能够抑制恶性疟原虫 Dd2 菌株、3D7 菌株生长，其 EC50值分别为155 nM、136 nM。Antimalarial agent 12 对大肠杆菌的 MIC>250,000 nM，也能够作用于 HEK-293 和 hPHep 细胞系，其 CC50值为 10,000-50,000 nM。
T62300	Antimalarial agent 11
	Antimalarial agent 11 (compound 1) 一种有效的抗疟 (antimalarial) 剂，是一种螺环色烷。Antimalarial agent 11 具有良好的抗氯喹 Dd2 菌株的效果 (EC50: 350 nM)。Antimalarial agent 11 能够作用于 D6 (EC50: 1.48 μM) 和 ARC08-022 (EC50: 1.81 μM) 。
T36649	AN3661
	AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains, Ugandan field isolates, and murine P. berghei and P. falciparum infections[1]. AN3661 is active at nanomolar (IC50=20-56 nM) concentrations against P. falciparum laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is simi...
T38269	Purfalcamine
	Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2]. Purfalcamine has low activity against Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3)[1]. Purfalcamine (225, 450 nM) has no effect on the parasitemia in the first 32 hours. After about 40 hours, paras...

化合物

FR900098 (sodium salt)

Antimalarial agent 12

Cat.No: T63456

Synonym:

Target:

Antimalarial agent 11

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03497	AKR1C2 Protein, Human, Recombinant (His) AKR1C2,HBAB,SRXY8,AKR1C-pseudo,aldo-keto reductase ...	Human	E. coli
	AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. AKR1C2 gene shares high sequence identity with three other gene ...
TMPJ-00207	AKR1C2 Protein, Human, Recombinant 3-Alpha-HSD3,Chlordecone Reductase Homolog HAKRD,2-...	Human	E. coli
	Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol).

重组蛋白

AKR1C2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03497

Species: Human

Expression System: E. coli

AKR1C2 Protein, Human, Recombinant

Cat.No: TMPJ-00207

Species: Human

Expression System: E. coli

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