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153

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20907	DBC 3,4,5,6-Dibenzocarbazole	Others	Others
	DBC, a ubiquitous environmental pollutant, induces significant DNA strand break levels and micronuclei in HepG2 cells.
T20214	Bucladesine Bucladesina,DT 5621,DBC-AMP,Actosin	Others	Others
	Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is capable of permeating the cell membrane. Bucladesine is a phosphodiesterase inhibitor. The compound is used in a wide variety of research applications because
T15067	DBCO-NHS ester	Others	Others
	DBCO-NHS ester 是一种 ADC 连接剂，可裂解的 3 单元 PEG，还可以用于合成抗体药物共轭物 (ADC)。
T15069	DBCO-PEG4-Biotin ADIBO-NH-PEG2-Biotin	Others	Others
	DBCO-PEG4-Biotin (ADIBO-NH-PEG2-Biotin) 是一种 azadibenzocyclooctyne-biotin 衍生物，含有生物素基团和 4 个 PEG。DBCO-PEG4-Biotin 是一种用途广泛的生物素酰化试剂，能通过无铜催化烷基叠氮化反应 (SPAAC) 将生物素的一部分引入叠氮标记的生物分子中。
T15073	DBCO-PEG4-NHS ester	PROTAC Linker	PROTAC
	DBCO-PEG4-NHS ester 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T77948	Tri-GalNAc-DBCO	PROTACs	PROTAC
	Tri-GalNAc-DBCO是一种PIP-GalNAc 偶联物，通过无铜菌株促进的叠氮化物-炔烃环加成与非特异性标记抗体上的叠氮化物偶联，可结合ASGPR以驱动蛋白质下调和靶向蛋白质降解的化合物。
T15076	DBCO-S-S-PEG3-biotin 生物素-PEG3-二硫-DBCO	Others; PROTAC Linker	Others; PROTAC
	DBCO-S-S-PEG3-biotin 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T17791	DBCO-PEG3-NHS ester	Others	Others
	DBCO-PEG3-NHS ester是一种可降解的 ADC linker，可用于合成抗体偶联活性分子。
T15058	DBCO-amine
	DBCO-amine 是一种可切割的 ADC 接头，用于合成抗体-药物偶联物。
T17753	DBCO-mPEG (MW 5kDa)	Others	Others
	DBCO-mPEG (MW 5kDa) 是一种基于 PEG 的 PROTAC 连接物，可用于合成 PROTAC。
T9282	DBCO-C3-Acid DBCO-ACID	Others	Others
	DBCO-(CH2)3-Acid 是一种用于抗体-药物偶联物的 Click Chemistry 中间体，可用以合成 ADC linker。
T17859	DSPE-PEG4-DBCO	PROTACs	PROTAC
	DSPE-PEG4-DBCO 是一种属于 PEG 类的 PROTAC linker。DSPE-PEG4-DBCO 可细胞成像和生物医学研究中用作生物材料。
T18137	m-PEG12-DBCO	Others	Others
	m-PEG12-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17748	DBCO-CONH-S-S-NHS ester	Others	Others
	DBCO-CONH-S-S-NHS ester is a disulfide-linked ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T17804	DBCO-PEG5-DBCO	Others	Others
	DBCO-PEG5-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17839	DNP-PEG4-DBCO	Others	Others
	DNP-PEG4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17780	DBCO-PEG1	Others	Others
	DBCO-PEG1 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17805	DBCO-PEG6-amine	Others	Others
	DBCO-PEG6-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17775	DBCO-NHS ester 3	Others	Others
	DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].
T15063	DBCO-NHCO-PEG4-NH-Boc	Others	Others
	DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T17762	DBCO-NHCO-PEG13-NHS ester	Others	Others
	DBCO-NHCO-PEG13-NHS ester is a pegylated PROteolysis-TArgeting Chimera (PROTAC) linker, serving as a valuable tool for PROTAC synthesis[1].
T15075	DBCO-PEG5-NHS ester	Others	Others
	DBCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T16956	Sulfo DBCO-amine	Others	Others
	Sulfo DBCO-amine is an alkyl chain-derived PROTAC linker utilized for synthesizing PROTACs[1].
T17796	DBCO-PEG4-Desthiobiotin	Others	Others
	DBCO-PEG4-Desthiobiotin is a polyethylene glycol (PEG) derivative utilized as a linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17801	DBCO-PEG4-VA-PBD	Others	Others
	DBCO-PEG4-VA-PBD is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T15065	DBCO-NHCO-PEG5-NHS ester	Others	Others
	DBCO-NHCO-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs[1].
T17772	DBCO-NHCO-PEG6-maleimide	Others	Others
	DBCO-NHCO-PEG6-maleimide is a polyethylene glycol (PEG)-based linker compound employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17769	DBCO-NHCO-PEG3-Fmoc	Others	Others
	DBCO-NHCO-PEG3-Fmoc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17765	DBCO-NHCO-PEG2-CH2COOH	Others	Others
	DBCO-NHCO-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17815	DBCO-Val-Cit-PABC-OH	Others	Others
	DBCO-Val-Cit-PABC-OH is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs) [1].
T18341	Methyltetrazine-PEG12-DBCO	Others	Others
	Methyltetrazine-PEG12-DBCO is a polyethylene glycol (PEG)-based linker compound utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T17764	DBCO-NHCO-PEG2-Biotin	Others	Others
	DBCO-NHCO-PEG2-Biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17782	DBCO-PEG12-acid	Others	Others
	DBCO-PEG12-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T84734	DBCO-PEG4-GGFG-Dxd	Others	Others
	DBCO-PEG4-GGFG-Dxd作为一种点击化学试剂，是抗体-活性分子偶联物的关键组成部分，它结合了DNA拓扑异构酶I抑制剂Dxd与可裂解的ADC linker DBCO-PEG4-GGFG。此化合物利用DBCO基团与含Azide基团的分子之间通过菌株促进的炔-叠氮环加成反应(SPAAC)实现快速且特异的连接。
T39297	Bis-sulfone-PEG4-DBCO Bis-sulfone-PEG4-DBCO	Others	Others
	Bis-sulfone-PEG4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15059	DBCO-C6-acid	Others	Others
	DBCO-C6-acid is a non-cleavable linker utilized for the synthesis of antibody-drug conjugates (ADCs) and carmaphycin analogues[1].
T17742	DBCO-Biotin Azadibenzocyclooctyne-Biotin conjugate
	DBCO-Biotin (Azadibenzocyclooctyne-Biotin conjugate) 是一种基于烷基链的 PROTAC linker。
T17797	DBCO-PEG4-NH-Boc	Others	Others
	DBCO-PEG4-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18200	m-PEG4-NH-DBCO	Others	Others
	m-PEG4-NH-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17794	DBCO-PEG4-alcohol	Others	Others
	DBCO-PEG4-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15064	DBCO-NHCO-PEG4-NHS ester	Others	Others
	DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T18948	Cy5-DBCO DBCO-Sulfo-Cy5	Others	Others
	Cy5-DBCO (DBCO-Sulfo-Cy5) is a near-infrared (NIR) red fluorescent dye (λabs: 646 nm, λem: 670 nm). Cy5-DBCO is not suitable for staining intracellular components of the permeabilized cells because it may exhibit a high background.
T18410	N-DBCO-N-bis(PEG2-C2-NHS ester)	Others	Others
	N-DBCO-N-bis(PEG2-C2-NHS ester) is a Polyethylene Glycol (PEG) derived linker that finds utility in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
T17789	DBCO-(PEG2-VC-PAB-MMAE)2	Others	Others
	DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2. MMAE, a potent tubulin inhibitor, serves as the cytotoxic component in this formulation.
T17812	DBCO-SS-amine	Others	Others
	DBCO-SS-amine is a cleavable linker vital in ADC synthesis. DBCO-SS-amine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.
T15060	DBCO-Maleimide	Others	Others
	DBCO-Maleimide is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs). [1]
T18411	N-(DBCO-PEG4)-N-Biotin-PEG4-NHS	Others	Others
	N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].
T18970	DBCO-PEG12-TCO	Others	Others
	DBCO-PEG12-TCO contains a DBCO and a TCO moiety.
T15074	DBCO-PEG4-TAMRA	Others	Others
	DBCO-PEG4-TAMRA, contains a DBCO group, is a PEG-based TARMA dye. The TAMRA dye is a dye widely used in oligonucleotide labeling.
T17832	DM1-PEG4-DBCO	Others	Others
	DM1-(PEG)4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linker for the development of antibody-drug conjugates (ADCs). This conjugation aims to mitigate the systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging DM1’s capabilities as an antibody-conjugatable maytansinoid.

化合物

Cat.No: T20907

Synonym: 3,4,5,6-Dibenzocarbazole

Target: Others

Cat.No: T20214

Synonym: Bucladesina,DT 5621,DBC-AMP,Actosin

Target: Others

DBCO-NHS ester

Cat.No: T15067

Target: Others

DBCO-PEG4-Biotin

Cat.No: T15069

Synonym: ADIBO-NH-PEG2-Biotin

Target: Others

DBCO-PEG4-NHS ester

Cat.No: T15073

Target: PROTAC Linker

Tri-GalNAc-DBCO

Cat.No: T77948

Target: PROTACs

DBCO-S-S-PEG3-biotin

Cat.No: T15076

Synonym: 生物素-PEG3-二硫-DBCO

Target: Others, PROTAC Linker

DBCO-PEG3-NHS ester

Cat.No: T17791

Target: Others

Cat.No: T15058

DBCO-mPEG (MW 5kDa)

Cat.No: T17753

Target: Others

Cat.No: T9282

Synonym: DBCO-ACID

Target: Others

DSPE-PEG4-DBCO

Cat.No: T17859

Target: PROTACs

Cat.No: T18137

Target: Others

DBCO-CONH-S-S-NHS ester

Cat.No: T17748

Target: Others

DBCO-PEG5-DBCO

Cat.No: T17804

Target: Others

DNP-PEG4-DBCO

Cat.No: T17839

Target: Others

Cat.No: T17780

Target: Others

DBCO-PEG6-amine

Cat.No: T17805

Target: Others

DBCO-NHS ester 3

Cat.No: T17775

Target: Others

DBCO-NHCO-PEG4-NH-Boc

Cat.No: T15063

Target: Others

DBCO-NHCO-PEG13-NHS ester

Cat.No: T17762

Target: Others

DBCO-PEG5-NHS ester

Cat.No: T15075

Target: Others

Sulfo DBCO-amine

Cat.No: T16956

Target: Others

DBCO-PEG4-Desthiobiotin

Cat.No: T17796

Target: Others

DBCO-PEG4-VA-PBD

Cat.No: T17801

Target: Others

DBCO-NHCO-PEG5-NHS ester

Cat.No: T15065

Target: Others

DBCO-NHCO-PEG6-maleimide

Cat.No: T17772

Target: Others

DBCO-NHCO-PEG3-Fmoc

Cat.No: T17769

Target: Others

DBCO-NHCO-PEG2-CH2COOH

Cat.No: T17765

Target: Others

DBCO-Val-Cit-PABC-OH

Cat.No: T17815

Target: Others

Methyltetrazine-PEG12-DBCO

Cat.No: T18341

Target: Others

DBCO-NHCO-PEG2-Biotin

Cat.No: T17764

Target: Others

DBCO-PEG12-acid

Cat.No: T17782

Target: Others

DBCO-PEG4-GGFG-Dxd

Cat.No: T84734

Target: Others

Bis-sulfone-PEG4-DBCO

Cat.No: T39297

Synonym: Bis-sulfone-PEG4-DBCO

Target: Others

Cat.No: T15059

Target: Others

Cat.No: T17742

Synonym: Azadibenzocyclooctyne-Biotin conjugate

DBCO-PEG4-NH-Boc

Cat.No: T17797

Target: Others

m-PEG4-NH-DBCO

Cat.No: T18200

Target: Others

DBCO-PEG4-alcohol

Cat.No: T17794

Target: Others

DBCO-NHCO-PEG4-NHS ester

Cat.No: T15064

Target: Others

Cat.No: T18948

Synonym: DBCO-Sulfo-Cy5

Target: Others

N-DBCO-N-bis(PEG2-C2-NHS ester)

Cat.No: T18410

Target: Others

DBCO-(PEG2-VC-PAB-MMAE)2

Cat.No: T17789

Target: Others

DBCO-SS-amine

Cat.No: T17812

Target: Others

DBCO-Maleimide

Cat.No: T15060

Target: Others

N-(DBCO-PEG4)-N-Biotin-PEG4-NHS

Cat.No: T18411

Target: Others

DBCO-PEG12-TCO

Cat.No: T18970

Target: Others

DBCO-PEG4-TAMRA

Cat.No: T15074

Target: Others

DM1-PEG4-DBCO

Cat.No: T17832

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2787	Picroside I 6'-Cinnamoylcatalpol,胡黄连苦苷I	MMP; STAT	JAK/STAT signaling; Proteases/Proteasome; Stem Cells
	Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物，是有肝脏保护作用的代谢成分，可用于哮喘研究，有减轻炎症作用，还下调 pSTAT6 和 GATA3 表达。

天然产物

Cat.No: T2787

Synonym: 6'-Cinnamoylcatalpol,胡黄连苦苷I

Target: MMP, STAT

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