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Cat. No. | Product Name | Target | Signaling Pathways |
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T39440 |
CXCL12 ligand 1
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CXCL12 ligand 1 is the first ligand of the sY12-binding pocket on chemokine CXCL12 . | |||
T28893 |
SX-517
SX 517 |
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SX-517 is a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibits CXCL1-induced Ca(2+) flux (IC50 = 38 nM) in human PMNs. | |||
T75642 | Corydalmine hydrochloride | ||
Corydalmine hydrochloride 抑制某些植物病原体的孢子萌发以及腐生真菌。Corydalmine hydrochloride 具有口服活性,可用于缓解疼痛的研究。Corydalmine hydrochloride 通过抑制 NF-κB 依赖性的 CXCL1/CXCR2信号传导途径,可缓解 Vincristine 引起的神经性疼痛。 | |||
T83779 |
EP4 Antagonist 14
Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14 |
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EP4 antagonist 14是一种前列腺素E2(PGE2)受体亚型EP4的拮抗剂,其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募(IC50 = 0.9 nM)。EP4 antagonist 14(10 µM)能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达,这些mRNA编码Il-4、巨噬细胞甘露糖受体1(Mrc1)、几丁质酶样蛋白3(Chil3)、趋化因子(C-X-C)基序配体1(Cxcl1)、表达在髓样细胞上的触发受体2(Trem2)和精氨酸酶-1(Arg1)。在体内,EP4 antagonist 14(每天30 mg/kg),结合抗PD-1抗体,能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。 |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00006 |
CXCL1 Protein, Mouse, Recombinant (His)
Scyb1,Growth-regulated α,Mgsa,Gro1,Growth-... |
Mouse | HEK293 Cells |
Growth-regulated alpha protein (CXCL1,KC), is a member of the alpha chemokine subfamily, was initially identified as an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor. The N-terminal processed form KC(5-72) of the protein is produced by proteolytic cleavage after secretion from bone marrow stromal cells, and shows a highly enhanced hematopoietic activity. Mouse KC shows approximately 63% identity to that of mouse MIP-2. KC is also approximately 60% identical ... | |||
TMPY-00008 |
CXCL1 Protein, Rat, Recombinant
chemokine (C-X-C motif) ligand 1 (melanoma growth s... |
Rat | E. coli |
CXCL1 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.9 kDa and the accession number is P14095. | |||
TMPY-02868 |
CXCL1 Protein, Human, Recombinant
chemokine (C-X-C motif) ligand 1 (melanoma growth s... |
Human | E. coli |
CXCL1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.9 kDa and the accession number is P09341-1. | |||
TMPY-00433 |
CXCL1 Protein, Mouse, Recombinant
Gro1,Scyb1,gro,KC,Fsp,N51,chemoki... |
Mouse | E. coli |
CXCL1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is A2RTH0. | |||
TMPY-02026 |
CXCL1 Protein, Human, Recombinant (His & SUMO)
FSP,P450c21B,CYP21B,CAH1,GROa,SCY... |
Human | E. coli |
CXCL1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with His and SUMO tag. The predicted molecular weight is 21.3 kDa and the accession number is P09341-1. | |||
TMPY-02180 |
CXCL1 Protein, Human, Recombinant (His & NusA)
CA21H,CPS1,CYP21,GRO1,GR... |
Human | E. coli |
CXCL1 Protein, Human, Recombinant (His & NusA) is expressed in E. coli expression system with His and NusA tag. The predicted molecular weight is 65 kDa and the accession number is P09341-1. | |||
TMPY-02970 |
CXCL10 Protein, Human, Recombinant
IFI10,IP-10,chemokine (C-X-C motif) ligand... |
Human | E. coli |
CXCL10 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.8 kDa and the accession number is P02778. | |||
TMPY-05337 |
CXCL16 Protein, Human, Recombinant (His)
chemokine (C-X-C motif) ligand 16,CXCLG |
Human | HEK293 Cells |
CXCL16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q9H2A7. | |||
TMPY-03274 |
CXCL11 Protein, Human, Recombinant
SCYB9B,I-TAC,chemokine (C-X-C motif) ligand 11<... |
Human | E. coli |
I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC ... | |||
TMPK-00735 |
CXCL13/BCA-1 Protein, Mouse, Recombinant (His)
ANGIE,BLR1L,ANGIE2,BLC,SCYB13,BCA1 |
Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The pred... | |||
TMPY-03896 |
CXCL16 Protein, Canine, Recombinant (hFc)
chemokine (C-X-C motif) ligand 16 |
Canine | HEK293 Cells |
CXCL16 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.1 kDa and the accession number is XP_849304.2. | |||
TMPK-00734 |
CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc)
ANGIE,ANGIE2,BCA-1,BLR1L,BLC,BCA1... |
Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred... | |||
TMPK-00138 |
CXCL16 Protein, Mouse, Recombinant (hFc)
SR-PSOX,SCYB16,SRPSOX,CXCLG16, |
Mouse | HEK293 Cells |
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro... | |||
TMPY-03771 |
CXCL16 Protein, Canine, Recombinant (His)
chemokine (C-X-C motif) ligand 16 |
Canine | HEK293 Cells |
CXCL16 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.5 kDa and the accession number is XP_849304.2. | |||
TMPY-05618 |
CXCL14 Protein, Human, Recombinant, Biotinylated
MIP2G,BMAC,KS1,MIP-2g,chemokine (C-X-C motif) ligan... |
Human | E. coli |
CXCL14 Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 9.4 kDa and the accession number is O95715. | |||
TMPY-01269 |
CXCL16 Protein, Mouse, Recombinant (His)
CXCL16v2,b2b498Clo,SR-PSOX,Zmynd1... |
Mouse | HEK293 Cells |
CXCL16 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is A2CFE9. | |||
TMPJ-00008 |
CXCL10 Protein, Human, Recombinant (hFc & His)
INP10,10 kDa Interferon Gamma-Induced Prot... |
Human | HEK293 Cells |
Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemoattraction for activated T-lymphocytes, inhibition of angiogenesis, and antitumor activity. | |||
TMPY-03025 |
CXCL16 Protein, Rat, Recombinant (hFc)
chemokine (C-X-C motif) ligand 16 |
Rat | HEK293 Cells |
CXCL16 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46 kDa and the accession number is A0A6M4C4P9. | |||
TMPY-06582 |
CXCL14 Protein, Human, Recombinant (His)
SCYB14,BRAK,MIP2G,KS1,MIP-2g,chemokine (C-... |
Human | E. coli |
CXCL14 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 11.51 kDa and the accession number is O95715. | |||
TMPY-04984 |
CXCL17 Protein, Human, Recombinant (His)
Dcip1,UNQ473,DMC,VCC1,chemokine (C-X-C mot... |
Human | P. pastoris (Yeast) |
Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like ski... | |||
TMPY-04943 |
CXCL10 Protein, Rat, Recombinant (His)
chemokine (C-X-C motif) ligand 10,IP-10,Sc... |
Rat | P. pastoris (Yeast) |
CXCL10 Protein, Rat, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 10 kDa and the accession number is P48973. | |||
TMPK-00017 |
CXCL13/BCA-1 Protein, Human, Recombinant (hFc)
BCA1,BLR1L,BLC,SCYB13,ANGIE2,BCA-... |
Human | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred... | |||
TMPJ-01394 |
CXCL15 Protein, Mouse, Recombinant (His)
Lungkine,C-X-C motif chemokine 15,Small-inducible c... |
Mouse | HEK293 Cells |
Mouse C-X-C motif chemokine 15, also known as Cxcl15, is a secreted protein which is member of the ELR motif-containing CXC chemokines. It expressed at low levels in fetal lung, the expression restricted to the lung, produced by bronchoepithelial cells and is released into the airways. It plays an important role in lung-specific neutrophil trafficking during normal and inflammatory conditions. It also appears chemotactic for neutrophils. | |||
TMPK-00469 |
CXCL16 Protein, Human, Recombinant (hFc)
SR-PSOX,SCYB16,CXCL16,CXCL |
Human | HEK293 Cells |
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro... | |||
TMPJ-00952 |
CXCL12 Protein, Mouse, Recombinant
Sdf1,C-X-C motif chemokine 12,Thymic lymph... |
Mouse | E. coli |
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scaven... | |||
TMPY-00001 |
CXCL14 Protein, Mouse, Recombinant
MIP2gamma,Scyb14,BMAC,MIP2γ,bolekine,AI414... |
Mouse | E. coli |
CXCL14 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9.4 kDa and the accession number is Q9WUQ5. | |||
TMPY-03781 |
CXCL14 Protein, Human, Recombinant
SCYB14,MIP-2g,MIP2G,KS1,BRAK,NJAC,KEC,chem... |
Human | E. coli |
CXCL14 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9.4 kDa and the accession number is O95715. | |||
TMPY-02754 |
CXCL16 Protein, Rat, Recombinant (His)
chemokine (C-X-C motif) ligand 16 |
Rat | HEK293 Cells |
CXCL16 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is Q6AXU5. | |||
TMPK-01269 |
CXCL10 Protein, Cynomolgus, Recombinant (His)
IFI10,gIP-10,CXCL10,IP-<... |
Cynomolgus | E. coli |
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for lymphocytes. | |||
TMPK-00018 |
CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo)
BLC,SCYB13,ANGIE,ANGIE2,BCA-1,BLR1 |
Human | E. coli |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo) is expressed in E. coli expression system with N-His-Sum... | |||
TMPJ-00397 |
IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated
CD217,IL17RA,interleukin 17 recep... |
Human | HEK293 Cells |
CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines... |