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2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T76888 |
Quetmolimab
E-6011,KANAb 001 |
Others | Others |
Quetmolimab 是一种人源化靶向趋化因子配体 1 (CX3CL1) 的单克隆抗体,可用于研究类风湿性关节炎。 | |||
T14384 |
AZD8797
KAN-0440567,KAND567 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
AZD8797 (KAND567) 是一种可口服且具有选择性和有效性的人 CX3CR1 变构拮抗剂,对 CX3CR1 和 CXCR2 具有抑制作用,对SARS-CoV-2诱导的神经元损伤有潜在的保护作用,可防止癫痫发作后偏头痛模型大鼠痛觉过敏和小胶质细胞活化的恶化。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00721 |
CX3CL1/Fractalkine Protein, Mouse, Recombinant (His & Avi), Biotinylated
Neurotactin,CXC3C,ABCD-3,Fkn,Frac... |
Mouse | HEK293 Cells |
Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma. | |||
TMPJ-00673 |
CX3CL1/Fractalkine Protein, Mouse, Recombinant (His)
CXC3,Cx3c,NTN,Fkn,C3... |
Mouse | HEK293 Cells |
Fractalkine(CX3CL1) is a single-pass type I membrane protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytoplasmic tail. CX3CL1 exists in two forms: as a membrane-anchored or as a shed 80-95K glycoprotein. Soluble CX3CL1 is generated by limited proteolysis on the cell surface, and a disintegrin and metallopeptidase 10 (ADAM10) and ADAM17/tumor necrosis factor-α-converting enzyme (ADAM1... |