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Search Results for " cholesteryl ester transfer protein "

16

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2499	Torcetrapib CP-529414,托彻普	CETP	Metabolism
	是胆固醇酯转移蛋白 (CETP) 选择性抑制剂。根据人血浆的抑制曲线，Torcetrapib (CP-529414) 对CETP 的最有效浓度为 37 nM。
T6262	Evacetrapib LY2484595	CETP	Metabolism
	Evacetrapib (LY2484595) 是 CETP 的选择性抑制剂，在人血浆中，抑制人重组 CETP 蛋白 (IC50:5.5 nM) 和 CETP (IC50:36 nM) 活性。
T1928	Anacetrapib 安塞曲匹,MK-0859	CETP	Metabolism
	Anacetrapib (MK-0859) 是 CETP 的抑制剂，能够抑制 rhCETP (IC50:7.9±2.5 nM) 和 C13S CETP 突变型 (IC50:11.8±1.9 nM) 的活性。
T6048	Dalcetrapib JTT-705,达塞曲匹,RO4607381	CETP	Metabolism
	Dalcetrapib (RO4607381) 是rhCETP 抑制剂(IC50:0.2 μM)，具有增加血浆中HDL 胆固醇含量的作用。
T28225	Obicetrapib TA8995,AMG899,Obicetrapib (free base),AMG 899,AMG-899,Obicetrapib,TA-8995	CETP	Metabolism
	Obicetrapib (AMG-899) 是胆固醇酯转移蛋白的抑制剂。
T69672	MK-825
	MK-825 is a cholesteryl ester transfer protein (CETP) inhibitor.
T14976	CKD-519	Others	Others
	CKD-519 is a selective inhibitor of cholesteryl ester transfer protein (CETP). It inhibits CETP-mediated transfer of cholesteryl ester in human serum (IC50: 2.3 nM).
T68416	DRL-17822
	DRL-17822 is a Cholesteryl Ester Transfer Protein (CETP) inhibitor.
T13079	TAP311	CETP	Metabolism
	TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).
T39137	CETP-IN-4
	CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor.
T68265	PF-04445597
	PF-04445597 is a potent, orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP).
T36139	BMS-795311
	Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable. Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID:265...
T68503	Obicetrapib potassium
	Obicetrapib potassium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T68505	Obicetrapib sodium
	Obicetrapib sodium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T68504	Obicetrapib calcium
	Obicetrapib calcium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T38908	MK-8262
	MK-8262, an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor (IC 50 = 53 nM, log D = 5.3), is a bistrifluoromethyl analogue that shows promise in research related to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) with potential implications for coronary heart disease (CHD).

化合物

Cat.No: T2499

Synonym: CP-529414,托彻普

Target: CETP

Cat.No: T6262

Synonym: LY2484595

Target: CETP

Cat.No: T1928

Synonym: 安塞曲匹,MK-0859

Target: CETP

Cat.No: T6048

Synonym: JTT-705,达塞曲匹,RO4607381

Target: CETP

Cat.No: T28225

Synonym: TA8995,AMG899,Obicetrapib (free base),AMG 899,AMG-899,Obicetrapib,TA-8995

Target: CETP

Cat.No: T69672

Cat.No: T14976

Target: Others

Cat.No: T68416

Cat.No: T13079

Target: CETP

Cat.No: T39137

Cat.No: T68265

Cat.No: T36139

Obicetrapib potassium

Cat.No: T68503

Obicetrapib sodium

Cat.No: T68505

Obicetrapib calcium

Cat.No: T68504

Cat.No: T38908

Cat. No.	Product Name	Target	Signaling Pathways
TN5057	Stachybotramide	LDL	Metabolism
	Stachybotramide preferentially stimulate the plasma cholesteryl ester transfer protein (CETP)-mediated transfer of cholesteryl esters (CE) from high density lipoprotein (HDL) to both very low density lipoprotein (VLDL) and low density lipoprotein (LDL).

天然产物

Stachybotramide

Cat.No: TN5057

Target: LDL

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