首页工具

登录

搜索结果

Search Results for " cav3.2 "

11

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T8944	TTA-A2	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	TTA-A2 是一种选择性 T 型钙通道拮抗剂，是一种有效的抗惊厥药，可减少孕烷 X 受体的激活。它对 Cav3.1 (a1G) 和 Cav3.2 (a1H) 通道在 -80 mV 和- 100 mV 保持电位上具有同样的作用，IC50 值分别为 89 和 92 nM。它可用于多种人类神经系统疾病的研究，包括睡眠障碍和癫痫。
T12076	ML218 hydrochloride	Others	Others
	ML218 hydrochloride is a selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor (Cav3.2 and Cav3.3 with IC50s of 310 nM and 270 nM , respectively).
T63350	Cav 3.2 inhibitor 3
	Cav 3.2 inhibitor 3 是 Cav3.2 T-type Ca2+channel 的有效抑制剂 (IC50: 0.1534 μM)，且对 D2受体的结合亲和力很低。
T62586	Cav 2.2/3.2 blocker 1
	Cav 2.2/3.2 blocker 1 (Compound 9e) 是一种神经钙离子通道 (neuronal calcium channel) 阻断剂，能够作用于 Cav2.2 (IC50: 1.22 μM) 和 Cav3.2 (IC50: 80 μM)。Cav 2.2/3.2 blocker 1 可以穿透中枢神经系统。
T12076L	ML218	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ML218 是一种具有口服活性、选择性、高效性且可穿透血脑屏障的 T 型 Ca2+ 通道抑制剂（Cav3.2 和 Cav3.3 的 IC50 分别为 310 nM 和 270 nM）。ML218 可抑制丘脑下核（STN）神经元的突发性活动。
TP2003	Mambalgin 1
	Selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Binds to closed/inactive channel. Selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Increases late
T75954	Mambalgin 1 TFA
	Mambalgin 1 TFA, a selective inhibitor of ASIC1a (with IC50 values of 192 nM for human ASIC1a and 72 nM for the ASIC1a/1b dimer), preferentially binds to the channel in its closed/inactive state. It demonstrates selectivity for ASIC1a over a range of other channels, including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. In vivo, Mambalgin 1 TFA effectively prolongs the latency of the withdrawal response in mouse tail-flick and paw-flick tests.
T63606	Cav 3.2 inhibitor 2
	Cav 3.2 inhibitor 2 是一种 Cav3.2 T-type Ca2+channels 的抑制剂，-80mV 恒定电位下，其IC50=0.09339 μM。Cav 3.2 inhibitor 2 对小鼠 T 通道依赖性的躯体和内脏疼痛表现出有效的抑制作用。Cav 3.2 inhibitor 2 能够用于研究顽固性疼痛。
T64203	T-Type calcium channel inhibitor 2
	T-Type calcium channel inhibitor 2 (compound 6g) 是一种 T 型钙通道的有效抑制剂，能够作用于 Cav3.1 (α1G) (IC50: 31.0 μM)、Cav3.2 (α1H) (IC50: 83.1 μM)、Cav3.3 (α1I) (α1H) (IC50: 69.3 μM)。T-Type calcium channel inhibitor 2 对 A549、HCT-116 细胞表现出细胞毒性，IC50s 分别为5.0、6.4 μM。
T36070	(±)5(6)-EET
	5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhib...
T79195	Cav 3.2 inhibitor 4	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cav 3.2 inhibitor 4 (compound 21) 是高效的选择性 T 型钙通道 (Cav3.2) 抑制剂，具有外周限制性，其 IC50 值为 0.6 μM，适用于心房颤动研究。

化合物

Cat.No: T8944

Target: Calcium Channel

ML218 hydrochloride

Cat.No: T12076

Target: Others

Cav 3.2 inhibitor 3

Cat.No: T63350

Cav 2.2/3.2 blocker 1

Cat.No: T62586

Cat.No: T12076L

Target: Calcium Channel

Cat.No: TP2003

Mambalgin 1 TFA

Cat.No: T75954

Cav 3.2 inhibitor 2

Cat.No: T63606

T-Type calcium channel inhibitor 2

Cat.No: T64203

Cat.No: T36070

Cav 3.2 inhibitor 4

Cat.No: T79195

Target: Calcium Channel

Cat. No.	Product Name	Target	Signaling Pathways
T0928	L-Ascorbic acid 维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate	Apoptosis; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	L-Ascorbic acid (Vitamin C) 属于天然产物，是一种强效的还原剂和抗氧化剂。L-Ascorbic acid 具有抗细菌感染、解毒反应和胶原蛋白形成的作用。L-Ascorbic acid 被用于治疗坏血病。
T6674	L-Ascorbic acid sodium salt (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,抗坏血酸钠,Sodium L-ascorbate,维生素C钠	Apoptosis; Others; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others
	L-Ascorbic acid sodium salt (Vitamin C sodium salt) 是一种电子供体，是一种内源性抗氧化剂。它还是一种胶原沉积促进剂和弹性生成抑制剂。它选择性抑制 Cav3.2 通道(Cav3.2 channels)，IC50为 6.5 μM。

天然产物

L-Ascorbic acid

Cat.No: T0928

Synonym: 维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite

L-Ascorbic acid sodium salt

Cat.No: T6674

Synonym: (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,抗坏血酸钠,Sodium L-ascorbate,维生素C钠

Target: Apoptosis, Others, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼