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抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T6015 Cathepsin Inhibitor 1

Cysteine Protease Proteases/Proteasome
Cathepsin inhibitor 1 是Cathepsin 的选择性抑制剂,能够抑制CatL(pIC50:7.9)、CatL2(pIC50:6.7)、CatS(pIC50:6.0)、CatK(pIC50:5.5)和CatB(pIC50:5.2)。
T72447 SARS-CoV-2 Mpro-IN-5

SARS-CoV-2 Mpro-IN-5是一种针对主要蛋白酶(MPro)和组织蛋白酶L(CatL)的双重抑制剂,具备IC50s分别为1800 nM和145 nM。该化合物在对抗SARS-CoV2方面显示出显著的抗病毒活性,并能在表达hACE2的A549细胞中阻断SARS-CoV2复制,IC50值达14.7 nM。
T72446 SARS-CoV-2 Mpro-IN-4

SARS-CoV-2 Mpro-IN-4是针对主要蛋白酶(MPro)和组织蛋白酶L(CatL)的双重抑制剂,其IC50s分别为900 nM和60 nM。此化合物对SARS-CoV2展现出抗病毒活性,在hACE2表达的A549细胞中可有效阻断SARS-CoV2复制,其IC50值为8.2 nM。
T71295 SOR-C13

SOR-C13 is an inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT) transcription complex which may result in an inhibition of calcium-dependent cancer cell proliferation and an induction of apoptosis in t...

化合物

Cathepsin Inhibitor 1
Cat.No: T6015
Synonym:
Target: Cysteine Protease
SARS-CoV-2 Mpro-IN-5
Cat.No: T72447
Synonym:
Target:
SARS-CoV-2 Mpro-IN-4
Cat.No: T72446
Synonym:
Target:
SOR-C13
Cat.No: T71295
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN1249 3-Epiursolic acid

Cysteine Protease; Immunology/Inflammation related Immunology/Inflammation; Proteases/Proteasome
3-Epiursolic Acid 是一种三萜类物质,分离自桃金娘科植物,是组织蛋白酶 L 的竞争性抑制剂(IC50=6.5 μM,Ki=19.5 μM),对 cathepsin B 无明显作用。

天然产物

3-Epiursolic acid
Cat.No: TN1249
Synonym:
Target: Cysteine Protease, Immunology/Inflammation related
TargetMol Loading
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