Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T73042 |
CYP1B1-IN-5
|
P450 | Metabolism |
CYP1B1-IN-5 是一种具有选择性和高效性的细胞色素 P450 1B1 (CYP1B1) 抑制剂,IC50 为 4.7 nM。CYP1B1-IN-5 可用于研究与代谢相关的疾病。 | |||
T36696 |
DMBA
|
||
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increase... |