Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22680 |
CP-100356 hydrochloride
CP-100356 HCl,CP 100356 hydrochloride |
BCRP | Membrane transporter/Ion channel |
CP-100356 hydrochloride 是一种具有口服活性和低微摩尔的 MDR1 (P-gp) 和 BCRP 双重抑制剂,是核苷酸衍生的底物类似物,对 MDR1 介导的 Calcein-AM 转运 和 BCRP 介导的 Prazosin 转运有抑制作用。CP-100356 抑制 OATP1B1,可在黑暗中诱导气孔张开。 | |||
T70693 | MRT-92 HCl salt | ||
MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs that bind to a long and narrow cavity in the 7-transmembrane (7TM) domain. |