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19

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39137	CETP-IN-4
	CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor.
T10771	CETP-IN-3	Others	Others
	CETP-IN-3 is an inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP.
T6262	Evacetrapib LY2484595	CETP	Metabolism
	Evacetrapib (LY2484595) 是 CETP 的选择性抑制剂，在人血浆中，抑制人重组 CETP 蛋白 (IC50:5.5 nM) 和 CETP (IC50:36 nM) 活性。
T1928	Anacetrapib 安塞曲匹,MK-0859	CETP	Metabolism
	Anacetrapib (MK-0859) 是 CETP 的抑制剂，能够抑制 rhCETP (IC50:7.9±2.5 nM) 和 C13S CETP 突变型 (IC50:11.8±1.9 nM) 的活性。
T2499	Torcetrapib CP-529414,托彻普	CETP	Metabolism
	是胆固醇酯转移蛋白 (CETP) 选择性抑制剂。根据人血浆的抑制曲线，Torcetrapib (CP-529414) 对CETP 的最有效浓度为 37 nM。
T6048	Dalcetrapib JTT-705,达塞曲匹,RO4607381	CETP	Metabolism
	Dalcetrapib (RO4607381) 是rhCETP 抑制剂(IC50:0.2 μM)，具有增加血浆中HDL 胆固醇含量的作用。
T14976	CKD-519	Others	Others
	CKD-519 is a selective inhibitor of cholesteryl ester transfer protein (CETP). It inhibits CETP-mediated transfer of cholesteryl ester in human serum (IC50: 2.3 nM).
T36139	BMS-795311
	Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable. Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID:265...
T13079	TAP311	CETP	Metabolism
	TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).
T68504	Obicetrapib calcium
	Obicetrapib calcium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T30300	BAY-60-5521 UNII-I0J230BJOO,BAY 60-5521
	BAY-60-5521 is an effective cholesterol ester transfer protein (CETP) inhibitor.
T68265	PF-04445597
	PF-04445597 is a potent, orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP).
T68416	DRL-17822
	DRL-17822 is a Cholesteryl Ester Transfer Protein (CETP) inhibitor.
T38908	MK-8262
	MK-8262, an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor (IC 50 = 53 nM, log D = 5.3), is a bistrifluoromethyl analogue that shows promise in research related to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) with potential implications for coronary heart disease (CHD).
T69672	MK-825
	MK-825 is a cholesteryl ester transfer protein (CETP) inhibitor.
T68503	Obicetrapib potassium
	Obicetrapib potassium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T68505	Obicetrapib sodium
	Obicetrapib sodium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T15004	CP-532623	CETP	Metabolism
	CP-532623, a close structural analog of Torcetrapib, is a CETP inhibitor with highly lipophilic properties. It elevates high-density lipoprotein cholesterol.
T35813	CAY10592
	Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM) ...

化合物

Cat.No: T39137

Cat.No: T10771

Target: Others

Cat.No: T6262

Synonym: LY2484595

Target: CETP

Cat.No: T1928

Synonym: 安塞曲匹,MK-0859

Target: CETP

Cat.No: T2499

Synonym: CP-529414,托彻普

Target: CETP

Cat.No: T6048

Synonym: JTT-705,达塞曲匹,RO4607381

Target: CETP

Cat.No: T14976

Target: Others

Cat.No: T36139

Cat.No: T13079

Target: CETP

Obicetrapib calcium

Cat.No: T68504

Cat.No: T30300

Synonym: UNII-I0J230BJOO,BAY 60-5521

Cat.No: T68265

Cat.No: T68416

Cat.No: T38908

Cat.No: T69672

Obicetrapib potassium

Cat.No: T68503

Obicetrapib sodium

Cat.No: T68505

Cat.No: T15004

Target: CETP

Cat.No: T35813

Cat. No.	Product Name	Target	Signaling Pathways
TN5057	Stachybotramide	LDL	Metabolism
	Stachybotramide preferentially stimulate the plasma cholesteryl ester transfer protein (CETP)-mediated transfer of cholesteryl esters (CE) from high density lipoprotein (HDL) to both very low density lipoprotein (VLDL) and low density lipoprotein (LDL).

天然产物

Stachybotramide

Cat.No: TN5057

Target: LDL

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