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Targets Recommended: EGFR

4

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T8151 Mobocertinib

tak788

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Mobocertinib (tak788) 是可口服的EGFR 和HER2突变的抑制剂,具有抗肿瘤活性。
T76255 Certepetide

Certepetide (CEND-1),即双功能环肽(a.k.a. iRGD),是一种具有穿透肿瘤功能的多肽。通过与α-V整联蛋白(alphav-integrins)的RGD motif相互作用,以及激活神经纤毛蛋白1(NRP-1),Certepetide能够将实体瘤微环境转化成临时的活性分子通道,从而在肿瘤中累积。该化合物在胰腺癌和其他实体瘤的研究中具有应用潜力。
T76963 Certolizumab pegol

Certolizumab pegol (Certolizumab) 是经过重组和聚乙二醇化处理的人源化单克隆抗体抗原结合片段,它选择性地靶向并中和肿瘤坏死因子-α (TNF-α)。适用于类风湿关节炎和克罗恩病的研究领域。
T71843 HPA-12

HPA-12 is a novel potent inhibitor of cert, binding to the ceramide-binding pocket in the cert start domain

化合物

Mobocertinib
Cat.No: T8151
Synonym: tak788
Target: EGFR
Certepetide
Cat.No: T76255
Synonym:
Target:
Certolizumab pegol
Cat.No: T76963
Synonym:
Target:
HPA-12
Cat.No: T71843
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-03266 COL4A3BP Protein, Human, Recombinant (His & GST)

CERTL,GPBP,collagen, type IV, alpha 3 (Goodpasture ...

Human Baculovirus Insect Cells
COL4A3BP is a member of the StarD2 subfamily. It contains a pleckstrin homology domain at its amino terminus and a START domain towards the end of the molecule. COL4A3BP has a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. One isoform of COL4A3BP is also involved in ceramide intracellular transport. COL4A3BP specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as t...

重组蛋白

COL4A3BP Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-03266
Species: Human
Expression System: Baculovirus Insect Cells
TargetMol Loading
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