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Cat. No.	Product Name	Target	Signaling Pathways
T10747	CDK9-IN-9	CDK	Cell Cycle/Checkpoint
	CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).
T10746	CDK9-IN-8	CDK	Cell Cycle/Checkpoint
	CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).
T10742	CDK9-IN-10	CDK	Cell Cycle/Checkpoint
	CDK9-IN-10 是一种有效的 CDK9 抑制剂。CDK9-IN-10 是 PROTAC CDK9 degrader-2 的配体。
T10745	CDK9-IN-7	CDK	Cell Cycle/Checkpoint
	CDK9-IN-7 (compound 21e) 是一种高效选择性的，具有口服活性的 CDK9/cyclin T 抑制剂 (IC50=11 nM)，与抑制其他 CDK 相比更有效 (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM)。CDK9-IN-7 具有抗癌活性并没有明显的毒性。CDK9-IN-7 诱导非小细胞肺癌 (NSCLC) 细胞凋亡，在 G2 期阻滞细胞周期，并具有抑制非小细胞肺癌干细胞特性。
T14918	CDK9-IN-2 N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺	Others; CDK	Cell Cycle/Checkpoint; Others
	CDK9-IN-2 是一种特异性CDK9抑制剂。它在 A2058 皮肤细胞系（72 小时）和 H929 多发性骨髓瘤细胞系（72小时）的IC50分别为 7 nM 和 5 nM。
T39354	CDK9-IN-12 CDK9-IN-12
	CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC 50 value of 5.41 nM.
T10743	CDK9-IN-11	CDK	Cell Cycle/Checkpoint
	CDK9-IN-11 是一种有效的CDK9抑制剂，可作为 PROTAC CDK9 Degrader-1 的配体。
T10741	CDK9-IN-1	CDK	Cell Cycle/Checkpoint
	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
T79631	CDK9-IN-26	CDK	Cell Cycle/Checkpoint
	CDK9-IN-26 (化合物1d) 为CDK9抑制剂，具有0.18 µM的IC50值。
T40353	CDK7/9-IN-1 CDK7/9-IN-1
	CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for su...
T36743	CDK7/9 tide
	CDK7/9 tide is peptide substrate for CDK7 or CDK9[1]. [1]. Robert T, et, al. Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Front Chem. 2020 Feb 27; 8:147.
T40047	CDK6/9-IN-1 CDK6/9-IN-1
	CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.
T70897	Zotiraciclib HCl
	Zotiraciclib, also known as TG02 and SB1317, is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, w...
T70988	Ibulocydine
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...

化合物

Cat.No: T10747

Target: CDK

Cat.No: T10746

Target: CDK

Cat.No: T10742

Target: CDK

Cat.No: T10745

Target: CDK

Cat.No: T14918

Synonym: N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺

Target: Others, CDK

Cat.No: T39354

Synonym: CDK9-IN-12

Cat.No: T10743

Target: CDK

Cat.No: T10741

Target: CDK

Cat.No: T79631

Target: CDK

Cat.No: T40353

Synonym: CDK7/9-IN-1

Cat.No: T36743

Cat.No: T40047

Synonym: CDK6/9-IN-1

Zotiraciclib HCl

Cat.No: T70897

Cat.No: T70988

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