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Cat. No. Product Name Target Signaling Pathways
T36744 CDK9 Antagonist-1

CDK9 Antagonist-1

CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.

化合物

CDK9 Antagonist-1
Cat.No: T36744
Synonym: CDK9 Antagonist-1
Target:
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