Cat. No. | Product Name | Target | Signaling Pathways |
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T39372 |
CDK7-IN-1
CDK7-IN-1 |
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CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound 215). | |||
T40353 |
CDK7/9-IN-1
CDK7/9-IN-1 |
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CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for su... | |||
T62791 | CDK7-IN-16 | ||
CDK7-IN-16 (compound 9) 是一种 CDK 7 的有效抑制剂 (IC50: 1-10 nM)。CDK7-IN-16 能够用于研究抗癌,特别是转录异常的癌症。 | |||
T79729 |
EGFR/CDK2-IN-4
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EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EGFR/CDK2-IN-4(化合物4c)是一种EGFR与CDK-2的双重抑制剂,其IC50值分别为89.6 nM和165.4 nM。该化合物在MCF-7细胞中能诱导(apoptosis)凋亡,并导致细胞周期在S期停滞。EGFR/CDK2-IN-4显示出显著的抗癌细胞毒性,对MCF-7细胞的IC50为2.74 μM。 | |||
T79728 |
EGFR/CDK2-IN-3
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EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EGFR/CDK2-IN-3(compound 4b)是一种针对EGFR与CDK-2的双重抑制剂,分别具有71.7 nM和113.7 nM的IC50s。该化合物在MCF-7细胞中能诱导凋亡,导致细胞周期在S期停滞,并显示出对癌细胞的明显毒性,其对MCF-7细胞的IC50值为3.16 μM。 | |||
T79727 |
EGFR/CDK2-IN-2
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EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EGFR/CDK2-IN-2(compound 6a)是一种针对EGFR和CDK-2的双重抑制剂,具有19.6 nM和87.9 nM的IC50s。该化合物能在MCF-7细胞内诱导凋亡,并在S期引发细胞周期停滞。此外,EGFR/CDK2-IN-2展现出IC50为0.39 μM的显著抗癌活性,对MCF-7细胞具有强效的细胞毒性。 | |||
T79881 |
CDK7-IN-25
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CDK | Cell Cycle/Checkpoint |
CDK7-IN-25 (CY-16-1)为一CDK-7抑制剂,具有极低的半抑制浓度(IC50<1nM),主要用于癌症研究领域。 | |||
T72951 |
CDK4/6-IN-14
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CDK4/6-IN-14 是一种有效且高度选择性的 CDK4和 CDK6(CDK) 抑制剂,IC50分别为 10 nM 和 16 nM。CDK4/6-IN-14 的选择性是 CDK1、2、7 和 9 的 60 多倍,并且在其他 205 种激酶中表现出高选择性。 | |||
T36409 |
Roccellic Acid
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Roccellic acid is a lichen secondary metabolite that has been found in R. montagnei and has antibacterial and anticancer activities.1,2 It is active against the bacteria S. gordonii and P. gingivalis (MIC = 46.9 μg/ml for both).1 Roccellic acid (100 μg/ml) inhibits proliferation of MDA-MB-231, MCF-7, and DLD-1 cancer cells by 65.3, 75.8, and 87.9%, respectively.2 |1. Sweidan, A., Chollet-Krugler, M., Sauvager, A., et al. Antibacterial activities of natural lichen compounds against Streptococcus ... | |||
T37065 |
6-Chloro-2-fluoropurine
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6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV)in vitro.2 1.Wilson, S.C., Atrash, B., Barlow, C., et al.Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitorsBioorg. Med. Chem.19(22)6949-6965(2011) 2.... |