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5

抑制剂 & 化合物

33

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T62612	CD33 splicing modulator 1
	CD33 splicing modulator 1 (Compound 1) 是一种 CD33 splicing modulator。CD33/Siglec 3 是一种已知可调节小胶质细胞活性的髓系细胞表面受体。CD33 splicing modulator 1 加强了细胞 mRNA 池中外显子 2 的跳跃。CD33 splicing modulator 1 具有潜力进行包括阿尔茨海默病在内的神经退行性疾病的研究。
T82763	CD33 splicing modulator 1 hydrochloride
	"CD33splicing modulator 1 (Compound 1) hydrochloride 是一种调节CD33/Siglec 3活性的化合物。CD33/Siglec 3 为髓系细胞表面受体，涉及小胶质细胞功能。该化合物通过提升细胞mRNA池中外显子2的剪接变异，展现在神经退行性疾病研究中的应用潜力，包括阿尔茨海默病。"
T9901A-003	Gemtuzumab CDP-771,CMA-676
	Gemtuzumab(CMA-676) 是一种针对 CD33 抗原且由重组人源化 IgG4 抗体组成的单克隆抗体。Gemtuzumab 可用于合成一种抗体偶联化合物 (ADC)--Gemtuzumab ozogamicin 。Gemtuzumab 可用于研究急性髓性白血病。
T80858	Vixtimotamab TandAb T564,AMV-564
	Vixtimotamab (AMV-564; TandAb T564)为一种双特异性四价串联抗体 (TandAb)，专一性靶向CD33和CD3抗原，主要用于急性髓系白血病 (AML) 的相关研究。
T78047	Gemtuzumab ozogamicin
	Gemtuzumab ozogamicin为抗体药物偶联物，由针对CD33单克隆抗体与Calicheamicin细胞毒性衍生物构成，用于急性髓系白血病研究。

化合物

CD33 splicing modulator 1

Cat.No: T62612

CD33 splicing modulator 1 hydrochloride

Cat.No: T82763

Cat.No: T9901A-003

Synonym: CDP-771,CMA-676

Cat.No: T80858

Synonym: TandAb T564,AMV-564

Gemtuzumab ozogamicin

Cat.No: T78047

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02304	Siglec-3/CD33 Protein, Mouse, Recombinant (His) gp67,CD33 molecule,Siglec-3	Mouse	HEK293 Cells
	Siglec-3/CD33 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is Q63994-1.
TMPY-02409	Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His) CD33 molecule	Cynomolgus,Rhesus	HEK293 Cells
	Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is EHH59833.1&EHH30318.1.
TMPY-04952	Siglec-3/CD33 Protein, Human, Recombinant (His), Biotinylated CD33 molecule,p67,SIGLEC3,Siglec-3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is AAH28152.1.
TMPY-04805	Siglec-3/CD33 Protein, Human, Recombinant SIGLEC3,Siglec-3,CD33 molecule,p67	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 27.4 kDa and the accession number is AAH28152.1.
TMPY-03805	Siglec-3/CD33 Protein, Human, Recombinant (His) CD33 molecule,SIGLEC3,Siglec-3,p67	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is AAH28152.1.
TMPK-01300	Siglec-3/CD33 Protein, Cynomolgus, Recombinant (His) Siglec-3,CD33,Siglec3,gp67,p67,CD...	Cynomolgus	HEK293 Cells
	Siglec-3/CD33 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.83 kDa and the accession number is XP_005590138.1.
TMPK-00846	Siglec-3/CD33 Protein, Human, Recombinant (aa 18-259, hFc) CD33,CD33 molecule,gp67,...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (aa 18-259, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.6 kDa and the accession number is P20138-1.
TMPK-00843	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), FITC-Labeled CD33,CD33 molecule,gp67,...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1.
TMPY-05571	Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated CD33 molecule,Siglec-3,p67,SIGLEC3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
TMPK-00844	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi) p67,CD33 molecule,FLJ00391,Siglec3,Siglec-...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1.
TMPY-04808	Siglec-3/CD33 Protein, Mouse, Recombinant gp67,CD33 molecule,Siglec-3	Mouse	HEK293 Cells
	Siglec-3/CD33 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.6 kDa and the accession number is Q63994-2.
TMPY-05366	Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated CD33 molecule	Cynomolgus,Rhesus	HEK293 Cells
	Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is XP_005590138.1.
TMPK-00845	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated Siglec3,p67,FLJ00391,Siglec-3,gp67,CD33,	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1.
TMPY-05381	Siglec-3/CD33 Protein, Human, Recombinant (hFc) p67,CD33 molecule,SIGLEC3,Siglec-3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.5 kDa and the accession number is AAH28152.1.
TMPY-02263	Siglec-3/CD33 Protein, Mouse, Recombinant (hFc) CD33 molecule,gp67,Siglec-3	Mouse	HEK293 Cells
	Siglec-3/CD33 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q63994-1.
TMPY-03694	Siglec-3/CD33 Protein, Human, Recombinant (mFc) p67,Siglec-3,CD33 molecule,SIGLEC3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 29.5 kDa and the accession number is AAH28152.1.
TMPY-05572	Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated Siglec-3,p67,CD33 molecule,SIGLEC3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
TMPJ-00537	Siglec-3/CD33 Protein, Human, Recombinant (hFc & His) Myeloid Cell Surface Antigen CD33,CD	Human	HEK293 Cells
	CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are c...
TMPK-00217	Siglec-15 Protein, Human, Recombinant (His & Avi) Siglec15,CD33 molecule-like 3,HsT1361,...	Human	HEK293 Cells
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates..
TMPK-01296	Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated CD33 molecule-like 3,CD33	Cynomolgus	HEK293 Cells
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed...
TMPK-01295	Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi) CD33 molecule-like 3,Siglec15,CD<...	Cynomolgus	HEK293 Cells
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mam...
TMPK-00231	Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated CD33 molecule-like 3,Siglec15,CD<...	Mouse	HEK293 Cells
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylate...
TMPK-00718	Siglec-5 Protein, Human, Recombinant (His & Avi) CD170,CD33 antigen-like 2,OBBP2,O...	Human	HEK293 Cells
	Siglec-5 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.3 kDa and the accession number is O15389.
TMPK-00719	Siglec-5 Protein, Human, Recombinant (His & Avi), Biotinylated CD170,SIGLEC5,OBBP2,CD33 antigen-...	Human	HEK293 Cells
	Siglec-5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.3 kDa and the accession number is O15389.
TMPK-00729	Siglec-6 Protein, Human, Recombinant (His & Avi) SIGLEC6,OBBP1,CD327,CD33L1,CD...	Human	HEK293 Cells
	Siglecs (Sialic acid binding Ig-like Lectins) are I-type (Ig-type) lectins that belong to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains.Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
TMPK-00720	Siglec-5 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated CD170,CD33 antigen-like 2,OBBP2,S...	Human	HEK293 Cells
	Group B Streptococcus (GBS) causes invasive infections in human newborns. the GBS β-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes.the polymorphism could influence the risk of prematurity among human fetuses of mothers colonized with GBS. This first functionally proven example of a paired receptor system in the Siglec family has multiple implications for regulation of host immunity.
TMPJ-00434	Siglec-15 Protein, Cynomolgus, Recombinant (His) Siglec-15,CD33L3,Sialic acid-binding Ig-li...	Cynomolgus	HEK293 Cells
	Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47.
TMPJ-00217	Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated CD33L3,Siglec-15,Sialic acid-binding Ig-li...	Human	HEK293 Cells
	Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 58-75 KDa and the accession number is Q6ZMC9.
TMPJ-00225	Siglec-15 Protein, Mouse, Recombinant (His) Siglec-15,Sialic acid-binding Ig-like lectin 15,CD<...	Mouse	HEK293 Cells
	Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type I...
TMPJ-00669	Siglec-5 Protein, Human, Recombinant (His & Flag & hFc) Sialic acid-binding Ig-like lectin 5,OB-BP2,Obesity-binding ...	Human	HEK293 Cells
	Human Siglec-5 are Itype(Igtype) lectins belonging to the Ig superfamily,They are characterized by an N terminal Ig-like V type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2 type domains. SIGLEC5 has also been designated CD170, they are expressed by monocytic or myeloid lineage cells, and also found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. SIGLEC5 are...
TMPJ-01254	Siglec-F Protein, Mouse, Recombinant (His) sialic acid binding Ig like lectin 8,SAF2,SIGLEC-8,SIGLEC8L,...	Mouse	HEK293 Cells
	Siglec 5 to 11 share a high degree of sequence similarity with CD33/Siglec-3 both in their extracellular and intracellular regions. They are collectively referred to as CD33-related Siglecs. One remarkable feature of the CD33-related Siglecs is their differential expression pattern within the hematopoietic system. This fact, together with the presence of two conserved immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their cytoplasmic tails, suggests that CD33-related Siglecs are involv...
TMPJ-00426	Siglec-5 Protein, Cynomolgus, Recombinant (His) Sialic acid-binding Ig-like lectin 5,Siglec-5	Cynomolgus	HEK293 Cells
	Sialic acid-binding Ig-like lectin 5 is a protein that in Cynomolgus is encoded by the SIGLEC5 gene, Cynomolgus SIGLEC5 cDNA encodes 551 amino acids (aa) that include a 16 aa signal sequence, a 439aa extracellular domain (ECD) with three Ig-like domains, a transmembrane region and a cytoplasma tail. No Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biologic...
TMPJ-01187	Siglec-E Protein, Mouse, Recombinant (hFc) SiglecE,Siglec-E	Mouse	HEK293 Cells
	Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 ‑ 85 kDa member of the CD33‑related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec‑9 is the most likely human ortholog of mouse Siglec‑E. Siglec‑E is expressed as a heavily N...

重组蛋白

Siglec-3/CD33 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02304

Species: Mouse

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His)

Cat.No: TMPY-02409

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04952

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant

Cat.No: TMPY-04805

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (His)

Cat.No: TMPY-03805

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01300

Species: Cynomolgus

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (aa 18-259, hFc)

Cat.No: TMPK-00846

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), FITC-Labeled

Cat.No: TMPK-00843

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated

Cat.No: TMPY-05571

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00844

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Mouse, Recombinant

Cat.No: TMPY-04808

Species: Mouse

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated

Cat.No: TMPY-05366

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00845

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05381

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02263

Species: Mouse

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03694

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated

Cat.No: TMPY-05572

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00537

Species: Human

Expression System: HEK293 Cells

Siglec-15 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00217

Species: Human

Expression System: HEK293 Cells

Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01296

Species: Cynomolgus

Expression System: HEK293 Cells

Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi)

Cat.No: TMPK-01295

Species: Cynomolgus

Expression System: HEK293 Cells

Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated

Cat.No: TMPK-00231

Species: Mouse

Expression System: HEK293 Cells

Siglec-5 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00718

Species: Human

Expression System: HEK293 Cells

Siglec-5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00719

Species: Human

Expression System: HEK293 Cells

Siglec-6 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00729

Species: Human

Expression System: HEK293 Cells

Siglec-5 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00720

Species: Human

Expression System: HEK293 Cells

Siglec-15 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00434

Species: Cynomolgus

Expression System: HEK293 Cells

Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPJ-00217

Species: Human

Expression System: HEK293 Cells

Siglec-15 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00225

Species: Mouse

Expression System: HEK293 Cells

Siglec-5 Protein, Human, Recombinant (His & Flag & hFc)

Cat.No: TMPJ-00669

Species: Human

Expression System: HEK293 Cells

Siglec-F Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01254

Species: Mouse

Expression System: HEK293 Cells

Siglec-5 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00426

Species: Cynomolgus

Expression System: HEK293 Cells

Siglec-E Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01187

Species: Mouse

Expression System: HEK293 Cells

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