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Search Results for " cd123 "

Targets Recommended: Immunology/Inflammation related Interleukin

4

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76883	Talacotuzumab CSL 362,JNJ 56022473	Immunology/Inflammation related; Interleukin	Immunology/Inflammation
	Talacotuzumab (JNJ 56022473) 是一种含有修饰的 Fc 结构的IgG1 型完全人源化的 CD123 中和单克隆抗体。Talacotuzumab 对 CD123、CD32b/c、CD16-158F、CD16-158V 具有很高的亲和力， KD 分别为 0.43 nM、188 nM、46 nM、16.8 nM。Talacotuzumab 通过抑制 IL-3 与 CD123 结合进而抑制靶细胞中的 IL-3 信号传导。Talacotuzumab 诱导 Fc 区发生突变以增加对 CD16 (FcγRIIIa) 的亲和力，从而加强抗体依赖性细胞介导的细胞毒性 (ADCC)。Talacotuzumab 急性髓性白血病 (AML) 异种移植小鼠模型中抑制白血病细胞生长。
T76959	Vibecotamab
	Vibecotamab (XmAb14045) 是一种有效的针对 CD123和 CD3的双特异性抗体，可刺激 T 细胞介导的 CD123 表达细胞的靶向杀伤。Vibecotamab 具有抗肿瘤活性，可用于急性髓系白血病研究。
T76771	Pivekimab
	Pivekimab为针对白介素3(IL-3)及CD123的人源IgG1型单克隆抗体。适用于母细胞浆细胞样树突状细胞肿瘤(BPDCN)研究。
T77012	Flotetuzumab
	Flotetuzumab (MGD006; S80880) 是一种双特异性 CD123/CD3双亲和再靶向 (DART) 抗体。Flotetuzumab 通过同时结合靶细胞的 CD123和效应 T 细胞的CD3，而重新激活 T 细胞，导致 T 细胞介导的靶细胞的细胞毒性。Flotetuzumab 对小鼠中急性髓系白血病 (AML) 患者来源异种移植物 (PDX) 模型具有抑制效力。

化合物

Cat.No: T76883

Synonym: CSL 362,JNJ 56022473

Target: Immunology/Inflammation related, Interleukin

Cat.No: T76959

Cat.No: T76771

Cat.No: T77012

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01410	IL-3R alpha/CD123 Protein, Human, Recombinant (His) CD123,interleukin 3 receptor, alpha (low a...	Human	HEK293 Cells
	IL-3R alpha/CD123 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.5 kDa and the accession number is P26951-1.
TMPY-00592	IL-3R alpha/CD123 Protein, Mouse, Recombinant (His) IL-3R α/CD123,interleukin 3 receptor, alph...	Mouse	HEK293 Cells
	IL-3R alpha/CD123 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.9 kDa and the accession number is EDL20630.1.
TMPY-00076	IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc) IL-3R α/CD123,interleukin 3 receptor, alph...	Mouse	HEK293 Cells
	IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P26952-1.
TMPY-05418	IL-3R alpha/CD123 Protein, Human, Recombinant (hFc) IL3RX,IL-3R α/CD123,hIL-3Ra,IL3RY,interleu...	Human	HEK293 Cells
	IL-3R alpha/CD123 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59.8 kDa and the accession number is P26951-1.
TMPK-00242	IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, His & Avi), Biotinylated IL3RAY,IL-3R subunit alpha,IL-3 R α,IL-3 R alpha,IL3RA,IL-3 ...	Human	HEK293 Cells
	Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
TMPY-06793	IL-3R alpha/CD123 Protein, Human, Recombinant (His & Avi), Biotinylated interleukin 3 receptor, alpha (low affinity),interleukin 3 r...	Human	HEK293 Cells
	IL-3R alpha/CD123 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 36.34 kDa and the accession number is NP_002174.1.
TMPY-06744	IL-3R alpha/CD123 Protein, Human, Recombinant (hFc & Avi), Biotinylated IL3RX,IL3RAY,interleukin 3 receptor, α (low affinity),interl...	Human	HEK293 Cells
	IL-3R alpha/CD123 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 61.62 kDa and the accession number is NP_002174.1.
TMPY-04034	IL-3R alpha/CD123 Protein, Canine, Recombinant (His) interleukin 3 receptor, alpha (low affinity),interleukin 3 r...	Canine	HEK293 Cells
	IL-3R alpha/CD123 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.2 kDa and the accession number is XP_851626.3.
TMPY-06715	IL-3R alpha/CD123 Protein, Cynomolgus, Recombinant (His) IL-3R α/CD123,interleukin 3 receptor, alph...	Cynomolgus	HEK293 Cells
	IL-3R alpha/CD123 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.25 kDa and the accession number is G8F3K3.
TMPJ-00639	CD123 Protein, Cynomolgus, Recombinant (His) Interleukin-3 receptor subunit α,IL-3R subunit α,IL-3R-α,Int...	Cynomolgus	HEK293 Cells
	CD123 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 50-65 KDa and the accession number is G8F3K3.
TMPJ-00244	IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, hFc & Avi), Biotinylated IL-3R subunit α,IL-3RA,Interleukin-3 receptor subunit α,IL-3...	Human	HEK293 Cells
	IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 80-100 KDa and the accession number is P26951.
TMPJ-00251	IL-3R alpha/CD123 Protein, Mouse, Recombinant (aa 17-331, His) IL-3 receptor subunit alpha,IL-3R subunit α,Interleukin-3 re...	Mouse	HEK293 Cells
	IL-3R alpha/CD123 Protein, Mouse, Recombinant (aa 17-331, His) is expressed in HEK293 mammalian cells with C-8xHis tag. The predicted molecular weight is 50-65 KDa and the accession number is P26952.

重组蛋白

IL-3R alpha/CD123 Protein, Human, Recombinant (His)

Cat.No: TMPY-01410

Species: Human

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00592

Species: Mouse

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00076

Species: Mouse

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05418

Species: Human

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, His & Avi), Biotinylated

Cat.No: TMPK-00242

Species: Human

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06793

Species: Human

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06744

Species: Human

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Canine, Recombinant (His)

Cat.No: TMPY-04034

Species: Canine

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-06715

Species: Cynomolgus

Expression System: HEK293 Cells

CD123 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00639

Species: Cynomolgus

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, hFc & Avi), Biotinylated

Cat.No: TMPJ-00244

Species: Human

Expression System: HEK293 Cells

IL-3R alpha/CD123 Protein, Mouse, Recombinant (aa 17-331, His)

Cat.No: TMPJ-00251

Species: Mouse

Expression System: HEK293 Cells

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