Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27682 |
CCR2 antagonist 5
JNJ-41443532,JNJ-41443532 Free Base,JNJ 41443532,JNJ41443532 |
CCR | Immunology/Inflammation; Microbiology/Virology |
CCR2 antagonist 5 (JNJ-41443532) 是一种具有选择性和口服活性的 hCCR2 抑制剂,具有良好的结合亲和力 (IC50=37 nM) 和有效的功能拮抗作用 (chemotaxis IC50=30 nM)。JNJ-41443532 对 mCCR2 结合的 Ki 为 9.6 µM, 可用于研究炎症性疾病和糖尿病。 | |||
T35772 |
Emestrin
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Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg/ml, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestr... |