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Cat. No.	Product Name	Target	Signaling Pathways
T10707	CCK-B Receptor Antagonist 2	Others	Others
	CCK-B Receptor Antagonist 2 is a potent and orally active antagonist of Gastrin/CCK-B (IC50: 0.43 nM). It also inhibits gastrin/CCK-A activity (IC50: 1.82 μM).
T13261	CCK-B Receptor Antagonist 1	Others	Others
	CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor agonist and has the potential of reducing the secretion of gastric acid.
TP1197	Sincalide SQ19844,辛卡利特,CCK-8,Cholecystokinin octapeptide	Others	Others
	Sincalide (CCK-8) 是一种速效的胆囊收缩素的氨基酸多肽激素类似物，可在胆囊造影术中静脉使用。它的肝胆生理作用是增加胆汁的分泌，使胆囊收缩并使 Oddi 的括约肌松弛，从而使胆汁排入十二指肠。它是一种通过注射促进胆囊收缩并帮助诊断胆囊和胰腺疾病的药物。
T1052	Proglumide 二丙谷酰胺	cholecystokinin	GPCR/G Protein
	Proglumide (Binoside) 是一种非肽的、口服具有活性的胆囊收缩素(CCK)-A/B 受体拮抗剂。它能够选择性阻断 CCK 在中枢神经系统中的作用。它能够抑制胃分泌，具有保护胃十二指肠粘膜的能力，并表现出抗癫痫和抗氧化活性。
T16906	Sograzepide YM-220,Netazepide,YF 476	Others	Others
	Sograzepide is an effective and highly selective Gastrin/CCK-B antagonist (IC50: 0.1 nM), has an inhibitory effect on Gastrin/CCK-A activity (IC50: 502 nM). Sograzepide replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine, and cloned human Gastrin/CCK-B receptors (Ki: 0.068, 0.62 and 0.19 nM, respectively).
T22666	CI-988 CI 988	Others	Others
	CCK2 (CCK-B) receptor antagonist
T25139	BC 197 Boc-asp-tyr(SO3H)-ahx-lys-trp-ahx-asp-phe-NH2,BC197,BC-197
	BC 197 is a selective CCK-B agonist.
T27014	CI-1015 CI1015,CI 1015,PD 144598
	CI-1015 is a CCK-B receptor antagonist with oral activity.
T26197	Snf 8815 Snf8815,Snf-8815,28-Mephe-31-N-meile-cck (26-33)
	Snf 8815 is an antagonist of cholecystokinin-B (CCK-B).
T23946	DA-3934 UNII-J353803KRG
	DA-3934 has a high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors. DA-3934 and its methyl ester derivative inhibited pentagastrin-induced gastric acid secretion in rats in a dose-dependent manner.
T28331	PD 136450 Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189
	Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B)) receptor antagonists may help to elucidate the physiological role o
T27774	L-740093 L 740093
	L-740093 is a specific antagonist of CCK-B receptor.
T17274	YM022	CCR	Immunology/Inflammation; Microbiology/Virology
	YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively.
T26482	A-57696
	A-57696 is a cholecystokinin antagonist with selective for cortical CCK-B receptors (IC50 = 25 nM).
T62039	L-365260 hemihydrate
	L-365260 hemihydrate 是选择性的、具有口服活性的非肽胃泌素和脑胆囊收缩素受体 (CCK-B) 拮抗剂，Kis 值分别为 1.9 nM 和 2.0 nM。L-365260 hemihydrate 以竞争性方式与豚鼠胃泌素和脑 CCK 受体相互作用。
T12544	Proglumide hemicalcium	Others	Others
	Proglumide hemicalcium is a antagonist of nonpeptide and orally active cholecystokinin (CCK)-A/B receptors, has antiepileptic and antioxidant activities.
T27772	L-736380 L-736,380,L 736380,L736,380,L 736,380
	L-736380 is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), 1.7 mg/kg).
T8761	[Leu15]-Gastrin I human Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2	Others	Others
	[Leu15]-Gastrin I human (Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2) 基因编码人体内的蛋白质 [Leu15]-胃泌素 I。在人类染色体中，GAST 基因定位于 17q21.2。胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体前胃泌素。前胃泌素经过裂解和加工产生胃泌素，它对整个胃肠道上皮细胞具有营养作用。胃泌素对消化系统的生长至关重要，并刺激壁细胞产生胃酸。胃泌素通过称为胆囊收缩素(CCK) 或 CCK-B 受体 (CCK-BR) 的 G 蛋白偶联受体发挥其功能。胃泌素的释放受到食物的刺激，尤其是蛋白质饮食，并受到非常低的 pH 值的抑制。萎缩性胃炎、幽门螺杆菌感染和长期服用质子泵抑制剂感染可能导致胃泌素过度表达。胃腺癌显示高水平的胃泌素。

化合物

CCK-B Receptor Antagonist 2

Cat.No: T10707

Target: Others

CCK-B Receptor Antagonist 1

Cat.No: T13261

Target: Others

Cat.No: TP1197

Synonym: SQ19844,辛卡利特,CCK-8,Cholecystokinin octapeptide

Target: Others

Cat.No: T1052

Synonym: 二丙谷酰胺

Target: cholecystokinin

Cat.No: T16906

Synonym: YM-220,Netazepide,YF 476

Target: Others

Cat.No: T22666

Synonym: CI 988

Target: Others

Cat.No: T25139

Synonym: Boc-asp-tyr(SO3H)-ahx-lys-trp-ahx-asp-phe-NH2,BC197,BC-197

Cat.No: T27014

Synonym: CI1015,CI 1015,PD 144598

Cat.No: T26197

Synonym: Snf8815,Snf-8815,28-Mephe-31-N-meile-cck (26-33)

Cat.No: T23946

Synonym: UNII-J353803KRG

Cat.No: T28331

Synonym: Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189

Cat.No: T27774

Synonym: L 740093

Cat.No: T17274

Target: CCR

Cat.No: T26482

L-365260 hemihydrate

Cat.No: T62039

Proglumide hemicalcium

Cat.No: T12544

Target: Others

Cat.No: T27772

Synonym: L-736,380,L 736380,L736,380,L 736,380

[Leu15]-Gastrin I human

Cat.No: T8761

Synonym: Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

Target: Others

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