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Search Results for " caxii "

11

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T60930	CAXII-IN-1
	CAXII-IN-1 (Compound 17) 具有抗肿瘤活性，它是 CA XII 的选择性抑制剂。CAXII-IN-1 对 hCA XII 和 hCA IX 的 Ki 值分别为 3.8 nM 和 56.0 nM。
T2017	U-104 NSC-213841,MST-104	Carbonic Anhydrase	Metabolism
	U-104 (NSC-213841) 是 CA IX 和 CA XII 碳酸酐酶 (CA) 抑制剂，其 Ki 分别为 45.1 nM 和 4.5 nM。小鼠模型中，它能够表现出明显的抑制肿瘤生长的作用。
T63973	hCAXII-IN-3
	hCAXII-IN-3 (Compound 6o) 是人碳酸酐酶 XII（hCAXII）的选择性抑制剂 (Ki: 10.0 nM)。
T61769	hCAXII-IN-5
	hCAXII-IN-5 (compound 6o) is a highly effective and specific inhibitor of hCAXII. The compound exhibits impressive binding affinities, with Ki values of >10000, >10000, 286.1, and 1.0 nM for hCAI, hCAII, hCAIX, and hCAXII, respectively [1].
T63276	hCAXII-IN-4
	hCAXII-IN-4 是选择性的、有效的 CA XII 抑制剂，对人CA XII 的Ki 值为 6.4 nM。
T62101	hCAXII-IN-2
	hCAXII-IN-2 (compound 5i) 是一种人碳酸酐酶 XII (hCA XII) (Ki: 84.2 nM) 和 hCA IX (Ki: 268.5 nM) 的有效抑制剂，对 hCA I 和 hCA II 具有较低的活性。
T61219	hCAXII-IN-1
	hCAXII-IN-1 demonstrates selective inhibition of tumor-related subtypes HCA IX and XII, making it potential leading molecules in the development of novel cancer therapeutic drugs with new mechanisms of action.
T79411	hCAXII-IN-7	Carbonic Anhydrase	Metabolism
	hCAXII-IN-7 (compound 6e)为hCA XII抑制剂，且具备脑屏障通透性。此化合物能够诱导786-0、SF-539和HS 578 T细胞系的凋亡。
T61384	hCAIX/XII-IN-4
	hCAIX/XII-IN-4 (compound 6c) is a highly potent inhibitor of CAIX/XII. It exhibits Ki values of 4.5 nM, 23.6 nM, >10000 nM, and >10000 nM for CAXII, CAIX, CAI, and CAⅡ, respectively [1].
T61873	hCAIX/XII-IN-1
	hCAIX/XII-IN-1 是一种有效的CAIX/XII 抑制剂，KI 值分别为 0.48 μM 和 0.83 μM。hCAIX/XII-IN-1 显示出体外抗增殖活性。hCAIX/XII-IN-1 诱导 MCF-7 细胞凋亡apoptosis。
T36059	Dichlorphenamide-13C6 Dichlorphenamide-13C6
	Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc...

化合物

Cat.No: T60930

Cat.No: T2017

Synonym: NSC-213841,MST-104

Target: Carbonic Anhydrase

Cat.No: T63973

Cat.No: T61769

Cat.No: T63276

Cat.No: T62101

Cat.No: T61219

Cat.No: T79411

Target: Carbonic Anhydrase

Cat.No: T61384

Cat.No: T61873

Dichlorphenamide-13C6

Cat.No: T36059

Synonym: Dichlorphenamide-13C6

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00694	Carbonic Anhydrase 12 Protein, Human, Recombinant (His) HsT18816,FLJ20151,carbonic anhydrase XII,CA12,CAXII	Human	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is O43570-1.
TMPY-06944	Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated HsT18816,carbonic anhydrase XII,CAXII,FLJ20151,CA12	Human	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 33.45 kDa and the accession number is NP_001209.1.
TMPK-00478	Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His) CA12,CAXII,Carbonic anhydrase,CA-XII,Tumor antigen ...	Cynomolgus	HEK293 Cells
	Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Carbonic anhydrase XII (CA XII) is a key mediator of several signaling pathways that are involved in cancer development.

重组蛋白

Carbonic Anhydrase 12 Protein, Human, Recombinant (His)

Cat.No: TMPY-00694

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06944

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00478

Species: Cynomolgus

Expression System: HEK293 Cells

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