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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1824	TGR5 Receptor Agonist	GPCR19	GPCR/G Protein
	TGR5 Receptor Agonist 是一种TGR5(GPCR19)激动剂。
T63584	ATX inhibitor 12
	ATX inhibitor 12 是口服具有活力的 ATX 抑制剂 (IC50: 1.72 nM)。在 C57Bl/6J 小鼠中，口服剂量为 60 mg/kg 的 ATX inhibitor 12 时，能够有效抑制肺结构损伤，降低纤维化病变。ATX inhibitor 12 能够用于研究特发性肺纤维化 (IPF) 。
T23945	DA-11004 DA11004,UNII-48M66E9ER2
	DA-11004 is a potent NADP-dependent isocitrate dehydrogenase inhibitor (IC50: 1.49 μM for IDPc). DA-11004 inhibited fatty acid synthesis in adipose tissues via IDPc inhibition. It also decreased the plasma glucose levels and FFA in HF diet-induced obesity
T15043	D5D-IN-326	Others	Others
	D5D-IN-326 is an orally active delta-5 desaturase (D5D) inhibitor (IC50s: 72 and 22 nM for rat and human D5D in enzymic and cell-based assays). It has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in die
T36296	BIO5192 hydrate
	BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2]. The combination of BIO5192 hydrate (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg/kg; s.c; bid; during days...

化合物

TGR5 Receptor Agonist

Synonym: DA11004,UNII-48M66E9ER2

Cat. No.	Product Name	Target	Signaling Pathways
T7036	2,4'-Dihydroxybenzophenone	Antioxidant	oxidation-reduction
	2,4'-Dihydroxybenzophenone 可有效保护 C57BL/6J 小鼠免受 APAP 诱导的肝毒性。它对可卡因诱导的小鼠急性肝毒性和神经毒性具有保护作用。其机制可能与其抗氧化活性有关。