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Search Results for " c3b "

Targets Recommended: Others

3

抑制剂 & 化合物

23

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP2228	C3bot(154-182) C3bot (154-182)	Others	Others
	transferase-deficient neurotrophic fragment of clostridial C3 protein
T82798	C3bot(154-182) TFA
	C3bot(154-182) TFA 是C3 肽类化合物，能够通过促进脊髓损伤后下行纤维束的再生，增强其修复效能。此外，C3bot(154-182) TFA 或许能够促进中枢神经系统损伤后的轴突保护与修复，并有助于功能性恢复。
T77089	Mirococept
	Mirococept (APT070) 是一种抗体，靶向补体系统 (complement system) 的 C3b/C4b，也是一种膜定位的 C3转化酶抑制剂。Mirococept 减少 C 肽和促炎细胞因子的释放，并减少炎症细胞的浸润。Mirococept 减少胰岛内炎症，有利于胰岛移植。Mirococept 还抑制增加的肠和肺血管通透性以减少中性粒细胞流入。

化合物

C3bot(154-182)

Cat.No: TP2228

Synonym: C3bot (154-182)

Target: Others

C3bot(154-182) TFA

Cat.No: T82798

Cat.No: T77089

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05731	Complement C3 Protein, Human, Recombinant (His) HEL-S-62p,CPAMD1,ARMD9,C3b,ASP,C3a,AHUS5,complement...	Human	HEK293 Cells
	Complement C3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 186.43 kDa and the accession number is P01024.
TMPH-03273	Complement factor I Protein, Rat, Recombinant (His & Myc) If,Complement factor I,Cfi,C3B/C4B inactivator	Rat	Baculovirus Insect Cells
	Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 69.2 kDa and the accession number is Q9WUW3.
TMPK-01023	Complement factor I Protein, Mouse, Recombinant (His) FIC3b-INA,I factor (complement),IF,C3B/C4B...	Mouse	HEK293 Cells
	Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 66.39 kDa and the accession number is Q61129.
TMPH-01135	CR1 Protein, Human, Recombinant (GST) Complement receptor type 1,C3b/C4b receptor,C3B...	Human	E. coli
	CR1 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPK-00776	Complement factor I Protein, Human, Recombinant (His) FIC3b-INA,KAF,IF,CFI,I factor (complement),EC:3.4.2...	Human	HEK293 Cells
	Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 64.58 kDa and the accession number is P05156.
TMPY-00353	LRRC3B Protein, Human, Recombinant (hFc) LRP15,leucine rich repeat containing 3B	Human	HEK293 Cells
	LRRC3B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.7 kDa and the accession number is A1LNH5.
TMPY-03749	LC3B Protein, Human, Recombinant (His) microtubule-associated protein 1 light chain 3 beta,ATG8F,MA...	Human	E. coli
	MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. LC3B is a member of the MAP1 LC3 family. It is most abundantly expressed in the heart, brain, skeletal muscle, and testis. LC3B is a subunit of the neuronal microtubule and functions in the formation of autophagosomal...
TMPY-00088	LRRC3B Protein, Human, Recombinant (His) leucine rich repeat containing 3B,LRP15	Human	HEK293 Cells
	LRRC3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is A1LNH5.
TMPJ-01321	MAP1LC3B Protein, Human, Recombinant Autophagy-related ubiquitin-like modifier LC3 B,MAP1A/MAP1B ...	Human	E. coli
	Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in the MAP1LC3 subfamily (others include MAP1LC3A, MAP1LC3C, and MAP1LC3B2). It is moat abundantly expressed in heart, brain, skeletal muscle and testis. LMAP1LC3B is a subunit of neuronal microtubule and functions in formation of autophagosomal vacuoles (autophagosomes). It associat...
TMPJ-00501	CLEC3B Protein, Human, Recombinant (His) Plasminogen Kringle 4-Binding Protein,Tetranectin,TN,CLE...	Human	HEK293 Cells
	C-Type Lectin Domain Family 3 Member B (CLEC3B) is a serum and tissue protein and it contais a C-type lectin which binds to Ca++. CLEC3B is originally found in plasma, the concentrations approximately 10mg/l. It can bind to kringle 4 of plasminogen and enhance the activation of plaminogen to plasmin, catalyzed by tissue plasminogen activator in the presence of poly-D-lysine. In addition, CLEC3B may be involved in the packaging of molecules destined for exocytosis. Also, CLEC3B is best known as a...
TMPH-03272	Complement factor D Protein, Rat, Recombinant (His) Adipsin,Df,Adn,C3 convertase activator,Complement factor D,E...	Rat	P. pastoris (Yeast)
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Cobra venom factor,Complement C3 homolog,CVFk,CVF	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...
TMPH-03559	Sbi Protein, S. aureus, Recombinant (Avi & His & MBP), Biotinylated	Staphylococcus aureus	E. coli
	Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis. Sbi Protein, S. aureus, Recombinant (Avi & His & MBP), Biotinylated is expressed in E. coli expression system with N-MBP and C-6xHis-Avi tag. The...
TMPK-00570	CD46 Protein, Canine, Recombinant (His) CD46,AHUS2,TRA2.10,LOC609365,TLX,MCP,MIC10,Membrane cofactor	Canine	HEK293 Cells
	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. CD46 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells w...
TMPK-00532	CD46 Protein, Cynomolgus, Recombinant (His) CD46,MCP,TLX,MIC10,AHUS2,TRA2.10	Cynomolgus	HEK293 Cells
	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. CD46 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cel...
TMPH-03271	Complement factor D Protein, Rat, Recombinant (His & Myc) Adn,C3 convertase activator,Properdin factor D,Complement fa...	Rat	HEK293 Cells
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038.
TMPH-02845	Properdin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
TMPH-02844	Properdin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
TMPH-02921	SUSD4 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. SUSD4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.5 kDa and the accession number is Q8BH32.
TMPH-03578	SCIN Protein, S. aureus, Recombinant (His & Myc)	Staphylococcus aureus	E. coli
	Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses. SCIN Protein, S. aureus, ...
TMPH-02606	CR1L Protein, Mouse, Recombinant (His) Crry,Complement regulatory protein Crry,Complement component...	Mouse	E. coli
	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion. CR1L Prot...
TMPH-00534	Gelatinase Protein, Enterococcus faecalis, Recombinant (His & SUMO)	Enterococcus faecalis	E. coli
	Metalloprotease capable of the hydrolysis of insoluble hydrophobic substrates. Hydrolyzes azocoll and gelatin and, at a lower rate, soluble and insoluble collagens. Does not cleave short synthetic peptides. Preferentially hydrolyzes the 24-Phe-\|-Phe-25 bond in the insulin B-chain, followed by the 5-His-\|-Leu-6 bond. Inactivates endothelin-1, primarily by cleavage of the 5-Ser-\|-Leu-6 and 16-His-\|-Leu-17 bonds. Hydrolyzes the alpha chain of C3 to generate a C3b-like protein. Inhibits complement-m...
TMPJ-00809	CFH Protein, Human, Recombinant (His) CFH,Complement factor H	Human	HEK293 Cells
	Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessi...

重组蛋白

Complement C3 Protein, Human, Recombinant (His)

Cat.No: TMPY-05731

Species: Human

Expression System: HEK293 Cells

Complement factor I Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03273

Species: Rat

Expression System: Baculovirus Insect Cells

Complement factor I Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01023

Species: Mouse

Expression System: HEK293 Cells

CR1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01135

Species: Human

Expression System: E. coli

Complement factor I Protein, Human, Recombinant (His)

Cat.No: TMPK-00776

Species: Human

Expression System: HEK293 Cells

LRRC3B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00353

Species: Human

Expression System: HEK293 Cells

LC3B Protein, Human, Recombinant (His)

Cat.No: TMPY-03749

Species: Human

Expression System: E. coli

LRRC3B Protein, Human, Recombinant (His)

Cat.No: TMPY-00088

Species: Human

Expression System: HEK293 Cells

MAP1LC3B Protein, Human, Recombinant

Cat.No: TMPJ-01321

Species: Human

Expression System: E. coli

CLEC3B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00501

Species: Human

Expression System: HEK293 Cells

Complement factor D Protein, Rat, Recombinant (His)

Cat.No: TMPH-03272

Species: Rat

Expression System: P. pastoris (Yeast)

Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

Cat.No: TMPH-03038

Species: Naja kaouthia

Expression System: E. coli

Sbi Protein, S. aureus, Recombinant (Avi & His & MBP), Biotinylated

Cat.No: TMPH-03559

Species: Staphylococcus aureus

Expression System: E. coli

CD46 Protein, Canine, Recombinant (His)

Cat.No: TMPK-00570

Species: Canine

Expression System: HEK293 Cells

CD46 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00532

Species: Cynomolgus

Expression System: HEK293 Cells

Complement factor D Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03271

Species: Rat

Expression System: HEK293 Cells

Properdin Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02845

Species: Mouse

Expression System: HEK293 Cells

Properdin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02844

Species: Mouse

Expression System: E. coli

SUSD4 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02921

Species: Mouse

Expression System: E. coli

SCIN Protein, S. aureus, Recombinant (His & Myc)

Cat.No: TMPH-03578

Species: Staphylococcus aureus

Expression System: E. coli

CR1L Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02606

Species: Mouse

Expression System: E. coli

Gelatinase Protein, Enterococcus faecalis, Recombinant (His & SUMO)

Cat.No: TMPH-00534

Species: Enterococcus faecalis

Expression System: E. coli

CFH Protein, Human, Recombinant (His)

Cat.No: TMPJ-00809

Species: Human

Expression System: HEK293 Cells

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