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Cat. No. | Product Name | Target | Signaling Pathways |
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T37943 |
17-phenyl trinor Prostaglandin F2α isopropyl ester
17-phenyl trinor Prostaglandin F2α isopropyl ester |
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17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP r... | |||
T37945 |
Bimatoprost methyl ester
17-phenyl trinor Prostaglandin F2α methyl ester |
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Bimatoprost methyl ester is a lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. Esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid. |
Cat. No. | Product Name | Target | Signaling Pathways |
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T20939 |
Bimatoprost acid
17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α |
GPR | Endocrinology/Hormones; GPCR/G Protein |
Bimatoprost acid (17-phenyl trinor PGF2α) 是一种代谢稳定的 PGF2α 类似物,对 FP 受体具有潜在的拮抗活性。与 PGF2α 相比,它与绵羊黄体细胞上的 FP 受体结合的相对效力为 756%。 |