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Cat. No.	Product Name	Target	Signaling Pathways
T64117	BRD4-BD1-IN-2	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRD4-BD1-IN-2 是一种具有选择性和有效性的 BRD4-BD1 抑制剂，IC50 值为 2.51 µM ，是对 BRD4-BD2 抑制活性的 20 倍。BRD4-BD1-IN-2 可用于研究心血管疾病和癌症相关疾病。
T63707	BRD4-BD1/2-IN-2
	BRD4-BD1/2-IN-2 是 BRD4-BD2 的有效抑制剂，能够作用于 BRD4 BD2 (IC50<0.5 nM) 和 BRD4 BD1 (IC50<300 nM)。
T61791	BRD4-BD1/2-IN-1
	BRD4-BD1/2-IN-1 is a highly effective inhibitor of BRD4, specifically targeting the BRD4 BD-1 and BRD4 BD-2 domains with IC 50 values of <100 nM each (US20150148375A1, compound 5) [1].
T10773	CF53	Epigenetic Reader Domain; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	CF53 是一种高效、选择性、可口服的 BET 抑制剂，对 BRD4 BD1 的 Ki 值为 <1 nM，Kd 值为 2.2 nM，IC50 值为 2 nM；CF53 对 BRD2，BRD3，BRD4 和 BRDT BET 蛋白的 BD1 和 BD2 两个结构域都有高亲和性，对其选择性远高于非含溴结构域 BET 蛋白。CF53 在体外和体内都具有显著的抗肿瘤活性。
T10520	BET-IN-2	Epigenetic Reader Domain	Chromatin/Epigenetic
	BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).
T36628	PROTAC BRD4 Degrader-8 PROTAC BRD4 Degrader-8	PROTACs	PROTAC
	PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC50 of 28 nM[1].PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 11 nM[1].PROTAC BRD4 Degrader-8 (4 h) potently degra...
T36103	TW9 TW9
	TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μM) and for HDAC1 over HDAC2 (IC50= 2.5 μM). TW9 (50 nM) induces apoptosis in, and inhibits proliferation of, MIA PaCa-2 pancreatic cancer cells. It induces cell cycle arrest at the G1phase in HPAC pancreatic cancer cells when used at a concentration of 2 μM. TW9 acts synergistica...

化合物

BRD4-BD1-IN-2

Cat.No: T64117

Target: Epigenetic Reader Domain

BRD4-BD1/2-IN-2

Cat.No: T63707

BRD4-BD1/2-IN-1

Cat.No: T61791

Cat.No: T10773

Target: Epigenetic Reader Domain, CDK

Cat.No: T10520

Target: Epigenetic Reader Domain

PROTAC BRD4 Degrader-8

Cat.No: T36628

Synonym: PROTAC BRD4 Degrader-8

Target: PROTACs

Cat.No: T36103

Synonym: TW9

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