Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4610 |
Rimegepant
BMS 927711,BMS-927711,BMS927711,BHV-3000 |
CGRP Receptor | GPCR/G Protein; Neuroscience |
Rimegepant (BMS 927711) 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂,其 Ki=0.027 nM,IC50=0.14 nM。 | |||
T71955 |
C3001a
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C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous system to reduce the excitability of nociceptive neurons. In neuropathic pain, C3001a alleviated spontaneous pain and cold hyperalgesia. In a mouse model of acute pancreatitis, C3001a alleviated mechanical allodynia and inflammation. C3001a represents a lead compound which could a... | |||
T70837 | Rimegepant sulfate hydrate | ||
Rimegepant, also known as BMS-927711 and BHV-3000, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile. |