Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70038 |
MJN68390
|
Caspase | Apoptosis; Proteases/Proteasome |
MJN68390 对 CASP8 的表观 IC50值为 15 μM,对 CASP10 不显示活性。 | |||
T70039 | BIM-46174 | ||
BIM-46174 is a New Inhibitor of the Heterotrimeric Gα/Gβγ Protein Complex. BIM-46174 acts as a selective inhibitor of heterotrimeric G-protein complex. BIM-46174 prevents the heterotrimeric G-protein signaling linked to several GPCRs mediating (a) cyclic AMP generation (Gαs), (b) calcium release (Gαq), and (c) cancer cell invasion by Wnt-2 frizzled receptors and high-affinity neurotensin receptors (Gαo/i and Gαq). BIM-46174 inhibits the growth of a large panel of human cancer cell lines, includ... |