Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78183 |
B-Raf IN 15
|
Raf | MAPK |
B-Raf IN 15 是一种 BRAF 抑制剂,抑制 BRAFWT 和 BRAFV600E,可用于研究黑色素瘤和癌症,可用于优化成效果更好的BRA F抑制剂。 | |||
T6882 |
LY3009120
DP-4978 |
Raf; Autophagy | Autophagy; MAPK |
LY3009120 (DP-4978) 是一种泛RAF 抑制剂,其抑制BRAFV600E、BRAFWT 和CRAFWT 的IC50分别为 5.8、9.1和15 nM。 | |||
T79813 |
Raf inhibitor 3
|
Raf | MAPK |
Raf inhibitor3 (Example 30) 作为一种Raf抑制剂,对B-Raf和C-Raf展现出高效抑制作用,其IC50值均小于15 nM,主要应用于癌症研究领域。 | |||
T36681 |
Sorafenib N-oxide
|
||
Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibi... |