Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4201 |
Avibactam sodium
阿维巴坦,AVE-1330A,阿维巴坦钠,NXL-104 |
Antibacterial; Antibiotic | Microbiology/Virology |
Avibactam sodium (NXL-104) 是一种可逆的 β-内酰胺酶抑制剂,抑制 TEM-1,P99和KPC-2 β-内酰胺酶,IC50分别为8、80和38 nM。 | |||
T10422 |
Avibactam free acid
NXL-104 free acid |
Antibacterial | Microbiology/Virology |
Avibactam (NXL-104) free acid is a covalent and reversible inhibitor of non-β-lactam β-lactamase (IC50s: 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15). | |||
T60874 |
Avibactam sodium dihydrate
|
||
Avibactam sodium (NXL-104) dihydrate 抑制 CTX-M-15和 β-内酰胺酶 TEM-1,IC50值分别为 5 nM 和 8 nM。Avibactam sodium (NXL-104) dihydrate 是非 β-内酰胺 β-内酰胺酶的可逆共价抑制剂。 | |||
T60711 | Avibactam sodium hydrate | ||
Avibactam sodium hydrate (NXL-104 hydrate) 是 β-内酰胺酶的共价可逆抑制剂,不含β-内酰胺核心 。Avibactam sodium hydrate 抑制 β-内酰胺酶CTX-M-15和TEM-1,IC50分别为5 nM 和 8 nM。 | |||
T38941 |
FPI-1523 sodium
|
Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
FPI-1523 sodium 是阿维巴坦的衍生物,是一种强效的 β-内酰胺酶抑制剂,对 CTX-M-15 和 OXA-48 的 K d s 分别为 4 nM 和 34 nM。FPI-1523 sodium 对 PBP2 有抑制作用,其 IC 50 为 3.2 μM。FPI-1523 sodium具有相当高的抗菌活性。 | |||
T39758 |
ARX-1796
ARX-1796,AV-006 |
||
ARX-1796 (AV-006), an Avibactam prodrug, is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes. | |||
T38940 | FPI-1523 | ||
FPI-1523, a derivative of Avibactam, is a potent inhibitor of β-lactamase enzymes. It has Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. Additionally, FPI-1523 inhibits PBP2 with an IC50 of 3.2 μM and demonstrates significant antimicrobial activity. |